Sodium hypochlorite / Hypochlorous acid

**Sodium hypochlorite** (in the form of pH-balanced **hypochlorous acid**) is a topical antimicrobial and wound care agent. It assists in the mechanical removal of cellular debris, senescent cells, necrotic tissue, and foreign material from the skin and wound surface through debridement. It possesses broad-spectrum **antibacterial and antifungal action**. > **Clinical Pearl:** Unlike traditional bleach or Dakin's solution, modern veterinary hypochlorous acid formulations are pH-balanced to a physiological range, making them non-cytotoxic to healing fibroblasts and safe for use on delicate tissues.

กลไกการออกฤทธิ์: Hypochlorous acid (HOCl) is a potent oxidizing agent naturally produced by neutrophils during the oxidative burst. * **Mechanical action:** The spray application assists in the physical debridement and flushing of cellular debris and necrotic tissue. * **Antimicrobial action:** HOCl → oxidizes sulfhydryl enzymes and amino acids → disrupts bacterial cell walls and biofilms → leads to microbial cell death.

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