Tetanus antitoxin

Tetanus antitoxin is an antiserum used as a **preventive measure** in animals at risk of developing tetanus from wounds, and in the early stages of clinical tetanus. > **Clinical Pearl:** It is most effective when used immediately as clinical signs appear or when severe wound contamination makes progression likely. It is **less effective in established cases** because it cannot displace toxin already bound to neural receptors. Routine prophylaxis is not warranted in dogs and cats due to their very low natural risk of tetanus.

กลไกการออกฤทธิ์: Antibodies in the antiserum bind directly to **tetanus toxin** (tetanospasmin) in the systemic circulation. → Neutralizes free toxin before it can enter the nervous system. → **Cannot** displace or neutralize toxin that has already bound to neural receptors.

ข้อมูลอ้างอิงยาของ VetSheet มีไว้สำหรับสัตวแพทย์ผู้มีใบอนุญาตเพื่อช่วยในการตัดสินใจทางคลินิก ไม่ใช่สิ่งทดแทนการวินิจฉัยของผู้เชี่ยวชาญหรือฉลากล่าสุดของผู้ผลิต