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比沙可啶

Bisacodyl

4,4'-(2-Pyridinylmethylene)bis(phenol) diacetate

瀉藥 (刺激性)PORectal狗貓

別名: Dulcolax · Fleet Bisacodyl · Entrolax

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

—PO

劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。

各物種劑量

🌎 NA — North America🌍 EU — Europe

狗

適應症劑量途徑頻次療程地區
Constipation / Bowel Evacuation—PO——🌎 NA
Constipation5-15 mg/dogPO/Rectalprn—🌍 EU
  • Constipation / Bowel Evacuation: Listed for Dogs (D) in monograph index.
  • Constipation: Empirical dose. Onset of action 6-10 hours (oral) or 15-60 minutes (rectal).

貓

適應症劑量途徑頻次療程地區
Constipation / Bowel Evacuation—PO——🌎 NA
Constipation2-5 mg/catPO/Rectalprn—🌍 EU
  • Constipation / Bowel Evacuation: Listed for Cats (C) in monograph index.
  • Constipation: Empirical dose. Onset of action 6-10 hours (oral) or 15-60 minutes (rectal).

劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。

正在為病患診症？VetSheet 的 AI 會把藥物、劑量與療程直接寫入結構化診症筆記。了解 VetSheet 如何運作

概覽

​比沙可啶​是一種刺激性瀉藥，在獸醫學中主要用於治療便秘，或在手術、X光攝影或內視鏡檢查前排空腸道。

  • ​臨床要點​：由於它是一種刺激性瀉藥，僅應作短期使用。長期使用可能導致依賴性、正常腸道功能喪失以及嚴重的電解質失衡。

作用機制

Bisacodyl acts directly on the enteric nervous system.

  • Stimulates mucosal sensory nerve endings → increases parasympathetic reflexes → enhances peristaltic contractions.
  • Alters fluid and electrolyte absorption → increases intestinal fluid accumulation, which helps soften the stool and facilitate evacuation.

安全性與警告

禁忌症

  • Intestinal obstruction
  • Ileus
  • Gastrointestinal bleeding
  • Severe dehydration

不良反應

  • Abdominal cramping
  • Diarrhea
  • Nausea
  • Electrolyte imbalances (with chronic use)

注意事項

Warning: Do not crush or chew enteric-coated tablets. Administer whole to prevent severe gastric irritation.

  • Use with caution in dehydrated animals; ensure adequate hydration before and during therapy.
  • Avoid concurrent administration with milk or dairy products.

藥物相互作用

Antacids

Premature dissolution of the enteric coating, leading to severe gastric irritation and vomiting.

H2-Receptor Antagonists (e.g., Famotidine)

Increased gastric pH may cause premature release of the drug in the stomach.

監測

  • Fecal output and consistency
  • Hydration status
  • Electrolytes (if used for prolonged periods)

藥物動力學

半衰期

貓Unknown馬Unknown狗Unknown

吸收

Minimal systemic absorption following oral or rectal administration.

分佈

Acts locally in the gastrointestinal tract.

代謝

Hydrolyzed by intestinal enzymes to the active desacetyl metabolite.

排除

Excreted primarily in feces; small amounts absorbed are excreted in urine as glucuronide conjugates.

過量

Overdose may lead to severe diarrhea, abdominal cramping, and significant fluid and electrolyte loss (especially hypokalemia). Treatment is supportive, focusing on intravenous fluid therapy and electrolyte replacement.

可用產品

劑型

  • Tablets (enteric-coated)
  • Enema
  • Suppository

人用標示

  • Bisacodyl 5 mg enteric-coated tablets
  • Bisacodyl 10 mg suppositories
  • Bisacodyl 10 mg/30 mL enema

各地核准狀態

European Union✓ 已核准EMA
🐕 Dogs🐈 Cats

Available as Pharmacy (P) medicine.

United Kingdom✓ 已核准VMD
🐕 Dogs🐈 Cats

Available as Pharmacy (P) medicine.

暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Store at room temperature (15-30°C) in a tight, light-resistant container. Protect suppositories from heat.

飼主須知

​重要提示​：請勿將腸溶片壓碎或咀嚼。請嚴格按照處方給藥。

  • 確保您的寵物隨時有充足的新鮮飲水。
  • 如果您發現寵物出現嚴重腹瀉、腹痛跡象，或者給藥後24小時內沒有排便，請聯繫您的獸醫。
  • 請勿將此藥物與牛奶或抗酸藥一起服用。

VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用，不能取代專業判斷或廠方最新藥品說明書。