寶丹酮十一酸酯
Boldenone Undecylenate
17 beta-hydroxyandrosta-1,4-dien-3-one
別名: Equipoise · Vebonol · Ba-29038 · boldenone undecenoate
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| As an appetite stimulant | 5 mg (total dose) IM/SC every 7 days | IM/SC | q7d | — | 🌎 NA |
- As an appetite stimulant: Anabolic steroids not as effective as many other appetite stimulants and may be associated with hepatotoxicity
馬
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Debilitated horses (improvement in weight, haircoat, or general physical condition) | 1.1 mg/kg IM; may repeat in 3 week intervals | IM | q3w | — | 🌎 NA |
| Debilitated horses | 1 mg/kg IM; repeated at 3 week intervals | IM | q3w | — | 🌎 NA |
- Debilitated horses (improvement in weight, haircoat, or general physical condition): Most horses will respond with one or two treatments. ARCI UCGFS Class 4 Drug.
- Debilitated horses: ARCI UCGFS Class 4 Drug.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
寶丹酮十一酸酯 (Boldenone undecylenate) 是一種長效的注射型同化類固醇 (anabolic steroid)，衍生自睪固酮。在獸醫學上主要用於治療虛弱的馬匹，幫助改善體重、毛色及整體身體狀況。
在小動物醫學中，過去曾標示外使用於貓作為食慾促進劑，但由於具有肝毒性風險，目前已大多被更安全有效的替代藥物所取代。
臨床要點： 寶丹酮以十一酸酯的形式配製於芝麻油載體中，這會延遲其從肌肉注射部位的吸收，並提供長達數週的持續釋放效果。由於其促進肌肉生長的特性，在美國被列為第三級管制藥品 (C-III)，具有極高的人類濫用及非法流用風險。
作用機制
Boldenone works by binding to intracellular androgen receptors in muscle and other tissues → the receptor-steroid complex translocates to the nucleus → alters gene transcription → promotes protein synthesis, nitrogen retention, and tissue building (anabolism) while reversing catabolism.
- Erythropoiesis: Stimulates red blood cell production, likely by increasing the production of erythropoietic stimulating factor (erythropoietin).
- Endocrine Feedback: High doses cause negative feedback on the hypothalamus and pituitary gland → inhibits Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) → suppresses endogenous testosterone release and impedes spermatogenesis.
- Electrolyte Balance: Causes retention of nitrogen, sodium, potassium, and phosphorus, and decreases urinary excretion of calcium.
安全性與警告
禁忌症
- Stallions intended for reproduction
- Pregnant mares (Category X - risk of fetal masculinization)
- Non-pregnant mares intended for reproduction
- Horses intended for food purposes
- Patients with hepatic dysfunction
- Patients with hypercalcemia
- Patients with a history of myocardial infarction
- Patients with pituitary insufficiency
- Patients with prostate carcinoma or benign prostatic hypertrophy
不良反應
- Androgenic effects (over-aggressiveness)
- Detrimental effects on testis size and sperm production in males
- Altered sexual behavior, shortened estrus, and reduced pregnancy rates in females
- Clitoral enlargement in females
- Hepatotoxicity
- Sodium and water retention
注意事項
Pregnancy Category X: The risk of use outweighs any possible benefit due to fetal masculinization.
Hepatotoxicity: Anabolic steroids have the potential to cause hepatic toxicity; use with extreme caution and monitor liver enzymes.
Human Abuse Potential: Boldenone is a target for human abuse (bodybuilding/athletics). Veterinarians must be vigilant against diversion scams and ensure strict inventory control.
藥物相互作用
Anabolic agents may potentiate the effects of anticoagulants; monitoring of INR and dosage adjustment are recommended.
May enhance the edema that can be associated with ACTH or adrenal steroid therapy.
May decrease blood glucose and decrease insulin requirements; diabetic patients may need dosage adjustments.
監測
- Androgenic side effects (e.g., aggression, behavioral changes)
- Fluid and electrolyte status, if indicated
- Liver function tests, if indicated
- Red blood cell count and indices, if indicated
- Weight and appetite
藥物動力學
吸收
Considered a long-acting anabolic, with effects persisting up to 8 weeks due to the undecylenate ester and oil vehicle.
分佈
Unknown if the anabolic agents cross into milk.
過量
Sodium and water retention can occur after overdosage of anabolic steroids. It is suggested to treat supportively and monitor liver function should an inadvertent overdose be administered.
可用產品
劑型
- Injection (oil vehicle)
獸醫用
- Boldenone Undecylenate for Injection: 25 mg/mL in 10 mL vials
- Boldenone Undecylenate for Injection: 50 mg/mL in 10 mL & 50 mL vials; Equipoise (Pfizer); (Rx, C-III)
各地核准狀態
暫無法規資料: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Boldenone injection should be stored at room temperature; avoid freezing. Because boldenone injection is in an oil vehicle, it should not be physically mixed with any other medications.
飼主須知
重要安全提示： 由於具有被人類濫用的潛力，同化類固醇屬於管制藥品。寶丹酮必須存放在安全的地方，並嚴格防止兒童及未經授權的人員接觸。
- 監測肝臟問題： 如果您的寵物出現眼白或牙齦發黃（黃疸）、食慾下降或嚴重嗜睡，請立即聯繫您的獸醫師。
- 行為改變： 注意是否出現攻擊性增加或其他預期外的行為改變。
- 給藥方式： 本藥物透過注射給予。請嚴格遵循獸醫師安排的後續注射時間表。
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