布他磷與維生素B12 (氰鈷胺)
**布他磷與維生素B12 (Butaphosphan with Cyanocobalamin)** 是一種主要用於大型動物和經濟動物醫學的複合營養補充劑，提供注射用的有機磷和維生素B12來源。 * **布他磷**：一種支持能量代謝和營養吸收的有機磷化合物。 * **氰鈷胺**：維生素B12的合成形式，對細胞代謝、DNA合成和紅血球生成至關重要。 > **臨床要點**：在乳牛中，這種組合經常被用來管理圍產期的代謝需求。研究顯示，它可以增加產後葡萄糖的可用性，減少周邊脂肪的動員，並顯著降低成年母牛高酮血症（亞臨床酮症）的發生率。
作用機制: * **Butaphosphan** → Acts as a readily available source of phosphorus, a critical structural component of **ATP (adenosine triphosphate)**, nucleic acids, and cell membranes. It supports gluconeogenesis and overall energy utilization. * **Cyanocobalamin (Vitamin B12)** → Acts as a vital coenzyme for **methylmalonyl-CoA mutase** (crucial for the metabolism of propionate into glucose in ruminants) and **methionine synthase**. * **Synergistic Effect** → Together, they enhance energy metabolism, improve post-partum glucose availability, and decrease ketone body formation by optimizing the TCA cycle and reducing peripheral fat mobilization.
各物種劑量
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies (Adults) · 1-2 mL per 100 lbs body weight · SC, IM, or IV · repeat daily as needed · Volumes of more than 10 mL should be split and given at separate intramuscular or subcutaneous sites.
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies (Calves) · 2-4 mL per 100 lbs body weight · SC, IM, or IV · repeat daily as needed
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies · 1-2 mL per 100 lbs body weight · SC, IM, or IV · repeat daily as needed · Volumes of more than 10 mL should be split and given at separate intramuscular or subcutaneous sites.
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies (Poultry/Turkeys) · 1-3 mL per liter of drinking water · PO · repeat daily as needed
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies (Adults) · 2 - 5 mL per 100 lbs body weight · SC, IM, or IV · repeat daily as needed · Volumes of more than 10 mL should be split and given at separate intramuscular or subcutaneous sites.
- Prevention or treatment of phosphorus and Vitamin B12 deficiencies (Piglets) · 1-2.5 mL (total dose) per animal · SC, IM, or IV · repeat daily as needed
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
給藥途徑
禁忌症
- Hyperphosphatemia
不良反應
- None noted in the monograph
監測
- Serum phosphorus levels
- Resolution of clinical signs of deficiency
- Serum beta-hydroxybutyrate (BHBA) / ketone bodies in periparturient dairy cattle
過量
No specific information located regarding acute toxicity or overdosage.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。