甲殼素與碳酸鈣
Chitosan and Calcium Carbonate
Poly-D-glucosamine / Calcium carbonate
別名: Ipakitine · Epakitin · Poliglusam
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Chronic kidney disease | 200 mg/kg | PO | q12h | — | 🌍 EU |
- Chronic kidney disease: Mixed with food
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Chronic kidney disease | 200 mg/kg | PO | q12h | — | 🌍 EU |
- Chronic kidney disease: Mixed with food
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
這是一種結合甲殼素與碳酸鈣的口服粉劑，主要用於慢性腎病（CKD）犬貓的腸道磷結合劑與尿毒素吸附劑。通常在低磷飲食無法有效控制血磷時使用。
作用機制
Acts locally within the gastrointestinal tract.
- Calcium carbonate binds to dietary phosphate in the gut → forms insoluble calcium phosphate → excreted in feces, thereby preventing systemic absorption of phosphorus.
- Chitosan acts as an adsorbent for various uraemic toxins in the intestines, reducing their absorption and subsequent systemic accumulation.
安全性與警告
禁忌症
- Pre-existing hypercalcaemia
不良反應
- Hypercalcaemia (due to calcium carbonate absorption)
注意事項
Hypercalcaemia Risk: Monitor serum calcium levels, as the calcium carbonate component can be absorbed systemically. Lactose Content: The formulation contains 82% lactose. Use with caution in diabetic animals and those with known lactose intolerance.
藥物相互作用
Increased risk of hypercalcaemia when administered concurrently
監測
- Serum phosphate (at 4-6 week intervals to adjust dosage and achieve target concentrations)
- Serum total and ionized calcium (to monitor for hypercalcaemia)
藥物動力學
吸收
Chitosan is not absorbed systemically. A small portion of the calcium from calcium carbonate may be absorbed systemically, depending on vitamin D status and intestinal pH.
分佈
Remains primarily in the gastrointestinal tract.
代謝
Not metabolized systemically.
排除
Excreted primarily in the feces as insoluble complexes (e.g., calcium phosphate).
過量
Overdosage primarily increases the risk of hypercalcaemia due to excessive calcium carbonate intake.
Signs of hypercalcaemia may include polyuria, polydipsia, vomiting, lethargy, and weakness. Treatment involves discontinuing the supplement, feeding a low-calcium diet, and providing supportive fluid therapy (e.g., 0.9% NaCl) to promote calciuresis if clinically indicated.
可用產品
劑型
- Oral powder (8% chitosan, 10% calcium carbonate, 82% lactose)
獸醫用
- Ipakitine oral powder (general sale)
各地核准狀態
Available as a general sale nutritional supplement
Available as a general sale nutritional supplement
暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store in a cool, dry place. Keep the container tightly closed to protect from moisture.
飼主須知
請務必將此藥物與食物混合餵食，因為它需要在腸道內與食物中的磷結合。如果您的寵物出現嘔吐、虛弱或過度飲水等高血鈣症狀，請聯繫您的獸醫。由於含有乳糖，如果您的寵物有糖尿病或乳糖不耐症，請特別留意。
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