希米考昔
Cimicoxib
4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]benzenesulfonamide
別名: Cimalgex · Cimicoxibum
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Osteoarthritis and perioperative pain due to orthopaedic or soft tissue surgery | Not specified in text | PO | Not specified | 3-7 days | 🌍 EU |
- Osteoarthritis and perioperative pain due to orthopaedic or soft tissue surgery: Dose not explicitly stated in the provided snippet. Formulations available are 8 mg, 30 mg, and 80 mg.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
希米考昔是一種非類固醇消炎止痛藥（NSAID），屬於考昔類，對COX-2酵素具有高度選擇性。在獸醫學中主要用於緩解犬隻骨關節炎相關的疼痛與發炎，以及骨科或軟組織手術的圍手術期疼痛管理。
警告： 與所有NSAID一樣，存在胃腸道、腎臟和肝臟不良反應的風險。
臨床提示： 希米考昔製成適口性佳的咀嚼錠以提高服藥順從性，但必須嚴格放置於寵物無法觸及處，以防意外大量吞食造成過量。
作用機制
Cimicoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme.
→ This limits the conversion of arachidonic acid to prostaglandins (such as PGE2) that mediate pain, inflammation, and fever.
→ By sparing the COX-1 enzyme at therapeutic doses, it aims to maintain normal physiological functions like gastric mucosal protection and renal blood flow, though selectivity is not absolute and adverse effects can still occur.
安全性與警告
禁忌症
- Dogs less than 10 weeks of age
- Dogs weighing less than 2 kg
- Gastrointestinal disorders or ulceration
- Impaired hepatic, cardiac, or renal function
- Bleeding disorders
- Pregnancy and lactation
- Hypersensitivity to NSAIDs or sulfonamides
不良反應
- Vomiting
- Diarrhea
- Anorexia
- Gastrointestinal ulceration
- Elevated liver enzymes
- Renal impairment
- Lethargy
注意事項
Caution: Ensure the dog is adequately hydrated and normotensive before administration to minimize the risk of renal toxicity.
Do not use concurrently with corticosteroids or other NSAIDs. Monitor liver and kidney function during long-term use. Wash hands after handling the product.
藥物相互作用
Increased risk of severe gastrointestinal ulceration and bleeding
Increased risk of gastrointestinal and renal toxicity
Increased risk of nephrotoxicity and reduced hypotensive effect
Increased risk of nephrotoxicity
Competition for plasma protein binding sites, potentially increasing bleeding risk
監測
- Renal function (BUN, Creatinine, SDMA, Urinalysis)
- Hepatic function (ALT, ALP, Bilirubin)
- Clinical signs of GI upset (vomiting, diarrhea, melena)
- Hydration status
藥物動力學
半衰期
吸收
Rapidly absorbed after oral administration. Food does not significantly alter bioavailability.
分佈
Highly protein-bound in plasma.
代謝
Extensively metabolized in the liver.
排除
Excreted primarily via feces (biliary route) and urine.
過量
Overdose may lead to severe gastrointestinal signs (vomiting, bloody diarrhea, ulceration), renal failure, and hepatic damage.
Treatment: Discontinue the drug immediately. Initiate supportive care including intravenous fluid therapy to support renal perfusion, gastroprotectants (e.g., omeprazole, sucralfate), and closely monitor renal and hepatic blood parameters.
可用產品
劑型
- 8 mg chewable tablet
- 30 mg chewable tablet
- 80 mg chewable tablet
獸醫用
- Cimalgex 8 mg chewable tablets
- Cimalgex 30 mg chewable tablets
- Cimalgex 80 mg chewable tablets
各地核准狀態
Not currently marketed in the US.
Authorized for use in dogs for osteoarthritis and perioperative pain.
Classified as POM-V (Prescription Only Medicine - Veterinarian).
暫無法規資料: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store at room temperature in a dry place. Keep blister packs in the outer carton to protect from light. Keep out of reach of children and animals.
飼主須知
希米考昔用於緩解您愛犬的疼痛和發炎，通常用於關節炎或手術後。
請嚴格按照獸醫的指示給藥。
警告： 如果您的狗出現食慾不振、嘔吐、腹瀉或排出黑色柏油狀糞便，請立即停藥並聯絡您的獸醫。
請隨時提供充足的飲水。由於這些藥錠帶有香味且可咀嚼，請將其安全存放在所有寵物接觸不到的地方，以防意外過量。未經獸醫同意，請勿給予其他止痛藥。
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