辛可芬與潑尼松龍
結合**辛可芬**（一種早期的非類固醇消炎止痛藥）與**潑尼松龍**（一種糖皮質激素）的複方藥物。歷史上用於控制犬的骨關節炎和發炎性疾病。 > **臨床提示：** 在現代獸醫學中，通常禁忌同時使用 NSAID 和皮質類固醇，因為這會顯著增加嚴重的胃腸道潰瘍和穿孔風險。這是一種傳統藥物（例如 PLT 錠劑），需要極其謹慎的監測，特別是辛可芬相關的肝毒性。
作用機制: **Cinchophen** acts as an NSAID by inhibiting **cyclooxygenase (COX)** enzymes → decreased synthesis of pro-inflammatory prostaglandins. **Prednisolone** is a synthetic glucocorticoid that binds to cytosolic receptors → alters gene transcription → inhibits **phospholipase A2** via lipocortin → decreases arachidonic acid release and reduces inflammatory cytokines.
給藥途徑
禁忌症
- Pre-existing gastrointestinal ulceration
- Hepatic impairment
- Renal impairment
- Concurrent use of other NSAIDs or corticosteroids
不良反應
- Gastrointestinal ulceration
- Hepatotoxicity
- Polyuria (PU)
- Polydipsia (PD)
- Polyphagia
- Vomiting
- Diarrhea
- Melena
藥物相互作用
- NSAIDs (other) · Increased risk of severe GI ulceration and perforation · major
- Corticosteroids (other) · Increased risk of severe GI ulceration and immunosuppression · major
- Other NSAIDs (e.g., Meloxicam, Carprofen) · Synergistic toxicity leading to severe gastrointestinal ulceration and perforation. · major
- Other Corticosteroids (e.g., Dexamethasone) · Synergistic toxicity leading to severe gastrointestinal ulceration and perforation. · major
- Furosemide · Increased risk of nephrotoxicity and gastrointestinal ulceration. · moderate
監測
- Clinical signs of GI ulceration (vomiting, melena, anorexia)
- Liver function tests (ALT, ALP, AST, Bilirubin)
- Renal parameters (BUN, Creatinine)
過量
Overdosage significantly increases the risk of **gastrointestinal perforation**, severe **hepatotoxicity**, and acute renal failure. Treatment is supportive, including GI protectants (e.g., omeprazole, sucralfate), intravenous fluid therapy, and hepatoprotectants.
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