辛可芬與潑尼松龍
Cinchophen and Prednisolone
2-phenylquinoline-4-carboxylic acid; 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
別名: PLT tablets · Prednoleucotropin · Cinchophenum · Quinophan · Atophan
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
各物種劑量
此藥的劑量資料尚未收錄於 VetSheet 藥典，以下其他章節資料完整。處方前請參閱最新藥品說明書。
概覽
結合辛可芬（一種早期的非類固醇消炎止痛藥）與潑尼松龍（一種糖皮質激素）的複方藥物。歷史上用於控制犬的骨關節炎和發炎性疾病。
臨床提示： 在現代獸醫學中，通常禁忌同時使用 NSAID 和皮質類固醇，因為這會顯著增加嚴重的胃腸道潰瘍和穿孔風險。這是一種傳統藥物（例如 PLT 錠劑），需要極其謹慎的監測，特別是辛可芬相關的肝毒性。
作用機制
Cinchophen acts as an NSAID by inhibiting cyclooxygenase (COX) enzymes → decreased synthesis of pro-inflammatory prostaglandins.
Prednisolone is a synthetic glucocorticoid that binds to cytosolic receptors → alters gene transcription → inhibits phospholipase A2 via lipocortin → decreases arachidonic acid release and reduces inflammatory cytokines.
安全性與警告
禁忌症
- Pre-existing gastrointestinal ulceration
- Hepatic impairment
- Renal impairment
- Concurrent use of other NSAIDs or corticosteroids
不良反應
- Gastrointestinal ulceration
- Hepatotoxicity
- Polyuria (PU)
- Polydipsia (PD)
- Polyphagia
- Vomiting
- Diarrhea
- Melena
注意事項
Animals must be strictly monitored for signs of gastrointestinal ulceration (e.g., melena, vomiting blood) and deterioration in liver function.
Warning: At the end of treatment, the dose must be tapered gradually to prevent Addisonian crisis due to adrenal suppression from the prednisolone component.
藥物相互作用
Increased risk of severe GI ulceration and perforation
Increased risk of severe GI ulceration and immunosuppression
Synergistic toxicity leading to severe gastrointestinal ulceration and perforation.
Synergistic toxicity leading to severe gastrointestinal ulceration and perforation.
Increased risk of nephrotoxicity and gastrointestinal ulceration.
監測
- Clinical signs of GI ulceration (vomiting, melena, anorexia)
- Liver function tests (ALT, ALP, AST, Bilirubin)
- Renal parameters (BUN, Creatinine)
藥物動力學
吸收
Well absorbed orally.
分佈
Widely distributed.
代謝
Hepatic metabolism (both components). Cinchophen is known for potential hepatotoxic metabolites.
排除
Renal and biliary excretion.
過量
Overdosage significantly increases the risk of gastrointestinal perforation, severe hepatotoxicity, and acute renal failure. Treatment is supportive, including GI protectants (e.g., omeprazole, sucralfate), intravenous fluid therapy, and hepatoprotectants.
可用產品
劑型
- Oral tablet: 200 mg cinchophen / 1 mg prednisolone
獸醫用
- PLT tablets (200 mg cinchophen / 1 mg prednisolone)
各地核准狀態
Cinchophen is largely obsolete in the US due to hepatotoxicity.
Available as legacy combination products like PLT in some regions.
Historically available as PLT tablets (POM-V), though clinical use has drastically declined in favor of safer alternatives.
暫無法規資料: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store at room temperature in a tightly closed container, protected from light and moisture. Normal safety and handling precautions should be observed.
飼主須知
請嚴格按照獸醫的指示給藥，最好與食物一起餵食。
重要提示： 密切注意胃潰瘍的跡象，例如嘔吐（特別是帶血或看起來像咖啡渣）、排出黑色柏油狀糞便或食慾不振。
由於含有類固醇成分，您可能會注意到寵物口渴、排尿和食慾增加。除非獸醫指示，否則請勿突然停藥，因為通常需要逐漸減少劑量。
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