攀唑
Climbazole
1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one
別名: Douxo Pyo · CLX wipes
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Dermatophyte and Malassezia skin infections | May be applied daily-weekly | topical | daily to weekly | Until clinical resolution | 🌍 EU |
- Dermatophyte and Malassezia skin infections: For shampoo formulations 5-10 minutes contact time is required. Additional systemic antifungal treatment may be required in generalized cases.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Dermatophyte and Malassezia skin infections | May be applied daily-weekly | topical | daily to weekly | Until clinical resolution | 🌍 EU |
- Dermatophyte and Malassezia skin infections: For shampoo formulations 5-10 minutes contact time is required. Additional systemic antifungal treatment may be required in generalized cases.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
攀唑是一種局部使用的咪唑類抗黴菌劑，在獸醫皮膚科中常與氯己定（chlorhexidine）合併使用，用於治療馬拉色菌（Malassezia）皮炎和皮癬菌病。
臨床提示： 雖然對局部或輕度表面酵母菌感染非常有效，但全身性或嚴重的病例通常需要同時進行全身性抗黴菌治療。攀唑與氯己定的協同作用能對繼發性細菌性膿皮症和酵母菌過度生長提供極佳的廣效覆蓋。
作用機制
Climbazole inhibits cytochrome P450-dependent 14-alpha-demethylase → blocks the synthesis of ergosterol in fungal cell membranes → causes increased cell wall permeability → allows leakage of cellular contents, ultimately leading to fungal cell death.
安全性與警告
禁忌症
- Known hypersensitivity to climbazole or other formulation ingredients
不良反應
- Mild skin irritation (rare)
- Erythema (rare)
注意事項
Avoid contact with the patient's eyes and mucous membranes. Crucial: For shampoo formulations, a 5-10 minute contact time on the skin is required before rinsing to ensure efficacy.
監測
- Resolution of clinical signs (pruritus, erythema, scaling, odor)
- Skin cytology to monitor Malassezia and bacterial populations
藥物動力學
半衰期
吸收
Minimal systemic absorption following topical application on intact skin.
分佈
Remains primarily in the stratum corneum and superficial epidermis.
代謝
Not extensively metabolized systemically due to poor absorption.
排除
Removed mechanically via desquamation and washing.
過量
Systemic overdose is highly unlikely due to the topical route of administration. Accidental ingestion of shampoos or wipes may cause mild, self-limiting gastrointestinal upset (hypersalivation, vomiting, diarrhea).
可用產品
劑型
- Topical shampoo
- Topical mousse
- Topical pads
- Topical wipes
獸醫用
- Douxo Pyo shampoo/mousse/pads (3% chlorhexidine + 0.5% climbazole + phytosphingosine)
- CLX wipes (chlorhexidine, Tris-EDTA, zinc gluconate, glycerine, climbazole, benzyl alcohol, propylene glycol)
各地核准狀態
Available as general sale (OTC) dermatological products.
Available as general sale (OTC) dermatological products.
暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store at room temperature. Keep containers tightly closed and protect from freezing or excessive heat.
飼主須知
請按照獸醫的指示使用本產品。
- 重要提示： 如果使用藥用洗毛精，必須搓揉起泡並讓其在皮膚上停留 5 到 10 分鐘後再沖洗。這段接觸時間對於藥物殺死酵母菌和細菌至關重要。
- 避免接觸寵物的眼睛或口腔。
- 如果使用後皮膚發紅、刺激或搔癢加重，請停止使用並聯繫您的獸醫。
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