克催瑪汝
抗黴菌藥 - 咪唑類
克催瑪汝是一種局部使用的咪唑類抗黴菌藥物,用於治療皮癬菌和酵母菌感染。通常配製成乳膏或溶液,有時會與皮質類固醇結合使用以治療發炎性黴菌性皮膚病。 **臨床提示:** 在獸醫學中,它通常用於局部的馬拉色菌性皮膚炎或局部皮癬菌症(錢癬)。
作用機制: Clotrimazole exerts its antifungal effect by inhibiting **cytochrome P450-dependent ergosterol synthesis**. Ergosterol is a vital component of the fungal cell membrane. Inhibition of ergosterol synthesis → disruption of fungal cell membrane permeability → leakage of intracellular contents → fungal cell death. It is effective against pathogenic dermatophytes, *Aspergillus* spp., and yeasts.
給藥途徑
Topical
禁忌症
- Hypersensitivity to clotrimazole or other azole antifungals
不良反應
- Local irritation
- Erythema
- Pruritus
監測
- Resolution of clinical signs (pruritus, erythema, alopecia)
- Fungal culture or cytology to confirm clearance of infection
過量
Overdose is highly unlikely with topical application. Ingestion of large amounts of cream or solution may cause mild gastrointestinal upset (vomiting, hypersalivation, diarrhea).
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。