第滅寧
Deltamethrin
(S)-alpha-cyano-3-phenoxybenzyl (1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate
別名: Canishield · Scalibor · Deltametrina · Deltamethrinum
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Prevention against ticks, fleas, sandflies and mosquitoes | One collar | Topical | q5-6months | 5-6 months | 🌍 EU |
- Prevention against ticks, fleas, sandflies and mosquitoes: Collar exerts full effect after 1 week. Canishield provides persistent flea killing activity for 16 weeks.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Any | Do not use | Topical | null | null | 🌍 EU |
- Any: Contraindicated due to severe pyrethroid toxicity in cats.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
第滅寧（Deltamethrin）是一種合成除蟲菊精類外用殺寄生蟲藥，主要透過浸漬項圈用於犬隻，以控制壁蝨、跳蚤、白蛉和蚊子。> 臨床警告： 對貓、水生動物和蜜蜂具有高度毒性。請勿用於貓，配戴項圈的犬隻亦不可進入天然水域游泳。
作用機制
Acts as a sodium 'open channel blocker' in the nerve membranes of arthropods. → Prolongs sodium channel opening → Causes continuous nerve depolarization → Results in muscular convulsions, paralysis, and death of the parasite. It also possesses significant repellent (anti-feeding) activity against ticks and flying insects.
安全性與警告
禁忌症
- Cats (highly toxic)
- Dogs less than 7 weeks old
- Dogs with existing skin lesions
不良反應
- Dermatitis or localized skin irritation around the neck
- Gastrointestinal disturbances (if ingested)
- Neuromuscular disturbances (if ingested)
注意事項
Wash hands thoroughly after fitting the collar.
Important: Avoid letting children, especially those under 2 years of age, touch, play with, or put the collar into their mouth.
Highly toxic to aquatic animals; remove the collar before allowing the dog to swim in rivers or lakes. Also toxic to bees and birds.
監測
- Signs of local skin irritation or dermatitis at the collar site
- Neurological signs (tremors, twitching) if accidental ingestion is suspected
藥物動力學
半衰期
吸收
Systemic absorption from the collar is minimal; the active ingredient spreads through the lipid layer of the skin and hair coat.
分佈
Distributes over the entire body surface via sebum and hair.
代謝
Any systemically absorbed deltamethrin is rapidly metabolized by the liver (ester hydrolysis and oxidation).
排除
Excreted primarily in feces and urine.
過量
Accidental ingestion of the collar can cause severe gastrointestinal and neuromuscular disturbances (tremors, hypersalivation, seizures).
Treatment: Diazepam should be administered in the event of accidental ingestion to control neurological signs. Provide supportive care.
可用產品
劑型
- Topical: 4% deltamethrin collar (0.76 g for small/medium dogs, 1 g for large dogs)
獸醫用
- Canishield 4% collar
- Scalibor Protectorband 4% collar
各地核准狀態
Regulated as a pesticide by the EPA rather than FDA.
Available OTC in many EU countries.
Non-Food Animal - Veterinarian, Pharmacist, Suitably Qualified Person.
暫無法規資料: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store in the original packaging at room temperature until ready to use.
飼主須知
- 請勿將此項圈用於貓，因為對貓具有高度毒性甚至致命。
- 項圈大約需要1週才能達到完全的防護效果。
- 處理或配戴項圈後請用肥皂和水洗手。
- 避免讓兒童（特別是2歲以下）把玩、觸摸或啃咬項圈。
- 在狗狗游泳前請取下項圈，因為此藥物對魚類和其他水生生物具有高度毒性。
- 注意狗狗頸部周圍是否有發紅、發癢或脫毛現象。如果出現這些情況，請取下項圈並諮詢獸醫師。
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