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去氧皮質酮

Desoxycortone pivalate

皮質類固醇 - 鹽皮質激素SC狗貓

別名: Zycortal · Desoxycortisone pivalate · DOCP

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

Initial dose 1.5-2.2 mg/kg (final dose can be between 1.0 and 2.7 mg/kg)SC· long-acting (interval not specified in text)· Long-term replacement
— 🐕

劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。

各物種劑量

🌎 NA — North America🌍 EU — Europe

狗

適應症劑量途徑頻次療程地區
Primary hypoadrenocorticism (Addison's disease)Initial dose 1.5-2.2 mg/kg (final dose can be between 1.0 and 2.7 mg/kg)SClong-acting (interval not specified in text)Long-term replacement🌍 EU
  • Primary hypoadrenocorticism (Addison's disease): Many authorities start at the lower dose of 1.5 mg/kg SC, particularly in larger dogs.

貓

適應症劑量途徑頻次療程地區
Primary hypoadrenocorticism (Addison's disease)Initial dose 2.2 mg/kgSClong-actingLong-term replacement🌍 EU
  • Primary hypoadrenocorticism (Addison's disease): Experience is limited but higher doses seem to be needed.

劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。

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概覽

長效型鹽皮質激素替代療法，用於治療患有原發性腎上腺皮質機能減退症（愛迪生氏病）的犬貓。開始治療前必須確診。若出現愛迪生氏危象，必須先進行靜脈輸液（生理食鹽水）補充水分。

作用機制

Acts as a mineralocorticoid replacement. It binds to mineralocorticoid receptors in the distal renal tubules → increases sodium reabsorption and promotes potassium excretion → restores electrolyte balance and maintains extracellular fluid volume and blood pressure.

安全性與警告

禁忌症

  • None strictly listed, but use with caution in congestive heart disease, severe renal disease, primary hepatic failure, or oedema

不良反應

  • Pain on injection (rarely repeated in the same animal)
  • Polyuria
  • Polydipsia
  • Hypokalaemia (with overdose)
  • Vomiting
  • Anorexia
  • Muzzle swelling
  • Anaphylaxis

注意事項

​Handling Precaution:​ The vials are stable for several months once opened. Before use, shake gently to resuspend the product and continue to move the loaded syringe before injection to prevent precipitation.

藥物相互作用

SpironolactoneMajor

Aldosterone antagonist; counteracts the effects of desoxycortone

FurosemideModerate

May excessively reduce potassium levels

ThiazidesModerate

May excessively reduce potassium levels

監測

  • Serum sodium and potassium levels
  • Hydration status
  • Renal function parameters (BUN, Creatinine)
  • Clinical signs of Addison's relapse or overdosage (PU/PD)

藥物動力學

吸收

Slowly absorbed from the subcutaneous injection site providing long-acting effects.

過量

Overdoses may cause polyuria and hypokalaemia. Monitor electrolytes closely if overdose is suspected.

可用產品

劑型

  • Injectable: 25 mg/ml suspension for subcutaneous injection

獸醫用

  • Zycortal 25 mg/ml injectable suspension

各地核准狀態

European Union✓ 已核准處方藥EMA
🐕 Dogs🐈 Cats

POM-V

United Kingdom✓ 已核准處方藥VMD
🐕 Dogs🐈 Cats

POM-V

暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Normal precautions should be observed. The vials, once opened, are stable for several months.

飼主須知

這是一種長期的荷爾蒙替代療法。請勿自行停藥。您的寵物需要定期進行血液檢查以監測電解質（鈉和鉀）。如果發現寵物過度飲水、排尿增加、嘔吐或精神不振，請立即聯繫獸醫。

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