雙氯酚
Dichlorophen
2,2'-Methylenebis(4-chlorophenol)
別名: Dicestal · Various AVM-GSL products · Dichlorophene
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Control of tapeworm infections (Taenia, Dipylidium) | 250 mg total dose (for dogs <2.5 kg); 500 mg per 2.5 kg (for dogs >2.5 kg) | PO | Single dose, repeat every 4-6 months | 1 day | 🌍 EU |
- Control of tapeworm infections (Taenia, Dipylidium): Give maximum 6 tablets at one time; give the rest 3 hours later if no vomiting. Best administered immediately before the main feed. May be given whole or crushed in food.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Control of tapeworm infections (Taenia, Dipylidium) | 250 mg total dose (for cats <2.5 kg); 500 mg per 2.5 kg (for cats >2.5 kg) | PO | Single dose, repeat every 4-6 months | 1 day | 🌍 EU |
- Control of tapeworm infections (Taenia, Dipylidium): Give maximum 6 tablets at one time; give the rest 3 hours later if no vomiting. Best administered immediately before the main feed. May be given whole or crushed in food.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
雙氯酚是一種主要用於犬貓的抗絛蟲藥物。它對絛蟲屬 (Taenia) 和 犬複孔絛蟲 (Dipylidium) 有效，但對包生絛蟲 (Echinococcus) 無效。受藥物影響的絛蟲會在消化道內分解，因此在給藥後排出的糞便中通常無法辨認出完整的蟲體。
臨床提示： 雙氯酚目前被視為較老舊的驅蟲藥。在現代獸醫學中，它已廣泛被吡喹酮 (Praziquantel) 所取代，因為後者具有更廣泛的抗菌譜（包括包生絛蟲）和更高的安全性。
作用機制
Dichlorophen acts by interfering with oxidative phosphorylation in the parasite → uncoupling of the electron transport chain → depletion of ATP (energy) reserves → paralysis, death, and subsequent disintegration of the tapeworm within the host's gastrointestinal tract.
安全性與警告
禁忌症
- Animals weighing < 1.25 kg
- Animals < 6 months of age
- Repeating treatment within 10 days
- Repeating treatment immediately if vomiting occurs shortly after dosing
不良反應
- Vomiting
- Salivation (rare)
- Hyperaesthesia (rare)
- Loss of coordination/ataxia (rare)
注意事項
Vomiting: If vomiting occurs shortly after dosing, do not repeat the treatment immediately. Age/Weight Restrictions: Strictly avoid use in puppies and kittens under 6 months of age or weighing less than 1.25 kg. Dosing Limits: Do not administer more than 6 tablets at one time. If a higher dose is required, split the dose and give the remainder 3 hours later (provided no vomiting has occurred).
監測
- Resolution of tapeworm segments (proglottids) in feces or around the perineum
- Vomiting post-administration
- Neurological signs (ataxia, hyperaesthesia) in sensitive individuals
藥物動力學
吸收
Poorly absorbed from the gastrointestinal tract, allowing it to act locally on intestinal parasites.
分佈
Remains primarily within the gastrointestinal lumen.
代謝
Any absorbed fraction is metabolized in the liver.
排除
Excreted primarily in the feces.
過量
Overdosage may lead to gastrointestinal distress (severe vomiting) and neurological signs including hypersalivation, hyperaesthesia, and loss of coordination (ataxia). Treatment is supportive and symptomatic.
可用產品
劑型
- Oral tablet: 250 mg, 500 mg, 750 mg
獸醫用
- 250 mg oral tablet
- 500 mg oral tablet
- 750 mg oral tablet
各地核准狀態
Authorized Veterinary Medicine - General Sales List (can be sold over the counter).
暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store at room temperature in a tightly closed container, protected from light and moisture.
飼主須知
- 給藥方式： 最好在每天的主食前立即給予，可整片吞服或壓碎混入食物中。
- 預期情況： 絛蟲會在體內被消化分解，因此您在寵物的糞便中通常不會看到完整的蟲體。
- 嘔吐處理： 如果寵物在服藥後不久嘔吐，請勿立即重複給藥。請聯繫您的獸醫師。
- 限制： 不適用於6個月以下或體重不足1.25公斤的寵物。
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用，不能取代專業判斷或廠方最新藥品說明書。