達特南
達特南是一種第三代新菸鹼類殺蟲劑，在獸醫學中主要用作局部外用的成蚤殺滅劑。**臨床提示：** 在犬隻中，通常與百滅寧（Permethrin，一種除蜱/蚊的除蟲菊酯）和百利普芬（Pyriproxyfen，一種昆蟲生長調節劑）結合使用，以提供廣效的體外寄生蟲控制。 > **警告：** 含有百滅寧的產品（如 Vectra 3D）對貓具有高度毒性。
作用機制: Dinotefuran acts as an agonist at insect **nicotinic acetylcholine receptors (nAChRs)**. It binds continuously to these receptors → causes continuous nerve stimulation → leads to tremors, paralysis, and death of the insect. **Synergistic activity** is observed when combined with permethrin in vitro and in vivo.
各物種劑量
- Flea, tick, and flying insect control · 6.4 mg dinotefuran/kg, 0.6 mg pyriproxyfen/kg and 46.6 mg permethrin/kg · topical · q4w · Continuous during parasite season · Apply topically to the skin as a spot-on. Vectra 3D formulation.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
給藥途徑
禁忌症
- Cats (specifically for permethrin-containing combination products like Vectra 3D)
- Known hypersensitivity to neonicotinoids
不良反應
- Application site reactions (erythema, pruritus, alopecia)
- Lethargy
- Gastrointestinal upset if ingested (hypersalivation, vomiting)
監測
- Efficacy of parasite control
- Application site for irritation or erythema
過量
Overdose of topical dinotefuran alone is generally well tolerated in dogs. However, ingestion or massive overdose of combination products containing permethrin can lead to **pyrethroid toxicity** (tremors, seizures, hypersalivation, hyperthermia). Treatment is supportive (e.g., methocarbamol for tremors, bathing with dish soap to remove unabsorbed product).
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。