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依尼康唑

Enilconazole

1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

抗黴菌藥 (咪唑類)Topical

別名: Imaverol · Imazalil

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

各物種劑量

此藥的劑量資料尚未收錄於 VetSheet 藥典，以下其他章節資料完整。處方前請參閱最新藥品說明書。

概覽

​依尼康唑 (Enilconazole)​ 是一種廣效的咪唑類抗黴菌藥物，主要在獸醫學中用於局部治療皮癬菌症（錢癬）。

​臨床要點：​ 它對常見的獸醫皮癬菌（如犬小孢癬菌、石膏樣小孢癬菌和鬚毛癬菌）非常有效。通常以濃縮液形式提供，必須在稀釋後作為洗劑或浸泡劑使用。

作用機制

Inhibition of cytochrome P450-dependent synthesis of ergosterol in fungal cells → increased cell wall permeability → leakage of cellular contents → fungal cell death.

安全性與警告

禁忌症

  • Known hypersensitivity to enilconazole or other imidazoles

不良反應

  • Mild skin irritation (rare)
  • Hypersalivation or vomiting if ingested

注意事項

​Warning:​ For topical use only. Must be diluted prior to use. Avoid contact with eyes. Prevent the animal from licking the treated area until completely dry.

監測

  • Resolution of skin lesions
  • Negative fungal cultures (typically 2 consecutive negative cultures)

藥物動力學

吸收

Poorly absorbed systemically after topical application.

分佈

Remains primarily in the stratum corneum and hair follicles.

代謝

Hepatic (for the small fraction absorbed).

排除

Feces and urine (for absorbed fraction).

過量

Systemic toxicity is highly unlikely following topical application. Accidental ingestion of the concentrated solution may cause gastrointestinal irritation, vomiting, and hypersalivation. Treatment is symptomatic and supportive.

可用產品

劑型

  • Topical: 100 mg/ml (10%) liquid

獸醫用

  • Imaverol 100 mg/ml (10%) concentrate for dip emulsion

各地核准狀態

European Union✓ 已核准處方藥EMA
🐕 Dogs🐈 Cats🐴 Horses🐄 Cattle

Available as a veterinary medicinal product in various EU member states.

United Kingdom✓ 已核准處方藥 · POM-VPSVMD
🐕 Dogs🐴 Horses🐄 Cattle

Classified as POM-VPS (Prescription Only Medicine - Veterinarian, Pharmacist, Suitably Qualified Person).

暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Store in the original container at room temperature. Protect from light. Diluted solutions should typically be used within the timeframe specified on the product packaging.

飼主須知

此藥物為濃縮浸泡劑，​必須​按照獸醫的指示加水稀釋後使用。

  • 使用海綿或沖洗的方式塗抹稀釋液，確保皮膚和毛髮完全浸透。
  • 塗抹後​請勿沖洗​；讓其自然風乾。
  • 在毛髮完全乾燥前，請防止寵物舔舐自己，以免引起腸胃不適。
  • 使用後請徹底洗手。

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