依西泮泰
依西泮泰（Epsiprantel）是一種專門用於犬貓的口服**抗絛蟲藥物**。 - **適應症**：有效清除犬隻的犬瓜實絛蟲（*Dipylidium caninum*）與豆狀帶絛蟲（*Taenia pisiformis*），以及貓隻的犬瓜實絛蟲與貓帶絛蟲（*Taenia taeniaeformis*）。 - **臨床要點**：與吡喹酮（Praziquantel）不同，依西泮泰在胃腸道的吸收極差，這使其具有極高的安全性且幾乎沒有全身性副作用。
作用機制: While the exact mechanism of action against cestodes is not fully elucidated, epsiprantel acts directly on the tapeworm: - **Calcium Dysregulation** → Induces severe tetany (muscle spasms) in the parasite. - **Attachment Disruption** → Causes the tapeworm to lose its grip on the host's intestinal mucosa. - **Integument Alteration** → Damages the worm's outer protective layer, rendering it highly vulnerable to digestion by the host animal's gastrointestinal enzymes.
各物種劑量
- Cestode infection (Dipylidium caninum, Taenia taeniaeformis) · 2.75 mg/kg · PO · once · Single dose · Cats up to 10 lb should receive one 12.5 mg tablet; cats 11-20 lb should receive one 25 mg tablet
- Cestode infection (Dipylidium caninum, Taenia pisiformis) · 5.5 mg/kg (2.5 mg/lb) · PO · once · Single dose · Round up to the next larger tablet size
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
給藥途徑
禁忌症
- Puppies less than 7 weeks of age
- Kittens less than 7 weeks of age
不良反應
- Vomiting (rare)
- Diarrhea (rare)
藥物相互作用
- Prokinetic agents · Theoretically may reduce the drug's efficacy by decreasing gastrointestinal transit time
- Fast-acting laxatives · Theoretically may reduce the drug's efficacy
監測
- Clinical efficacy (resolution of tapeworm infection)
過量
Acute toxicity resulting from an inadvertent overdose is highly unlikely due to poor systemic absorption. - **Cats**: Doses as high as 36X the recommended dose resulted in vomiting in some of the kittens tested. - **Dogs**: Single doses of 36X those recommended in dogs caused no adverse effects.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。