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氟比洛芬

Flurbiprofen

2-(2-fluoro-4-biphenylyl)propionic acid

非類固醇抗發炎藥 (NSAID) - 眼用Topical (Ophthalmic)狗貓

別名: Ocufen · Flurbiprofeno · Flurbiprofenum

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

1 drop in the affected eye(s)Topical· Every 30 minutes for 4 doses prior to surgery· Pre-operative

劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。

各物種劑量

🌎 NA — North America🌍 EU — Europe

狗

適應症劑量途徑頻次療程地區
Prevention of intraocular surgical miosis1 drop in the affected eye(s)TopicalEvery 30 minutes for 4 doses prior to surgeryPre-operative🌍 EU
Ocular inflammation (uveitis)1 drop in the affected eye(s)Topicalq6h to q12hAs directed by veterinarian🌍 EU
  • Prevention of intraocular surgical miosis: Standard pre-surgical protocol
  • Ocular inflammation (uveitis): Monitor for corneal ulceration

貓

適應症劑量途徑頻次療程地區
Prevention of intraocular surgical miosis1 drop in the affected eye(s)TopicalEvery 30 minutes for 4 doses prior to surgeryPre-operative🌍 EU
Ocular inflammation (uveitis)1 drop in the affected eye(s)Topicalq6h to q12hAs directed by veterinarian🌍 EU
  • Prevention of intraocular surgical miosis: Standard pre-surgical protocol
  • Ocular inflammation (uveitis): Monitor for corneal ulceration

劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。

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概覽

氟比洛芬是一種局部眼用非類固醇抗發炎藥 (NSAID)。主要用於預防眼內手術（如白內障手術）期間的術中瞳孔縮小，以及治療眼部發炎。

​臨床提示：​ 雖然在控制前葡萄膜炎和預防手術引起的瞳孔縮小方面非常有效，但局部 NSAID 藥物（如氟比洛芬）可能會延遲角膜上皮癒合，在已有角膜潰瘍的患者中應極度謹慎使用。

作用機制

Inhibits ​cyclooxygenase (COX)​ enzymes, thereby blocking the synthesis of prostaglandins from arachidonic acid. → Reduces ocular inflammation and provides analgesic action. → Prevents prostaglandin-mediated miosis (constriction of the iris sphincter) during intraocular surgery, acting independently of cholinergic mechanisms.

安全性與警告

禁忌症

  • Hypersensitivity to flurbiprofen or other NSAIDs
  • Active corneal ulceration (relative contraindication)
  • Bleeding disorders
  • Hypersensitivity to NSAIDs
  • Active intraocular bleeding
  • Corneal ulceration (use with extreme caution)
  • Epithelial herpes simplex keratitis

不良反應

  • Transient ocular stinging or burning upon application
  • Delayed corneal healing
  • Increased risk of ocular bleeding during surgery
  • Corneal melting (rare but severe)
  • Transient stinging or burning upon instillation
  • Ocular irritation
  • Increased bleeding tendency of ocular tissues (rare)

注意事項

​Warning:​ May delay corneal epithelial healing. Use with extreme caution in patients with pre-existing corneal ulcers or epithelial defects. Monitor closely for signs of corneal melting or worsening ulceration.

​Clinical Pearl:​ Patients with a known bleeding tendency or those receiving systemic medications that prolong bleeding time should be monitored closely, as topical NSAIDs may increase bleeding of ocular tissues during surgery.

藥物相互作用

Topical CorticosteroidsModerate

Concurrent use may increase the risk of delayed corneal healing and severe complications such as corneal melting.

Topical Prostaglandin Analogues (e.g., Latanoprost)Minor

NSAIDs may blunt the intraocular pressure-lowering efficacy of topical prostaglandins.

Topical prostaglandins (e.g., Latanoprost)Minor

NSAIDs may decrease the intraocular pressure-lowering efficacy of topical prostaglandin analogues.

監測

  • Resolution of ocular inflammation (flare and cells in the anterior chamber)
  • Intraocular pressure (IOP)
  • Maintenance of pupillary dilation during surgery
  • Corneal integrity (via fluorescein staining) if used long-term

藥物動力學

半衰期

貓Unknown for topical administration狗Unknown for topical administration

吸收

Absorbed systemically through the nasolacrimal duct and conjunctival vessels, but systemic levels remain very low.

分佈

Penetrates the cornea well to reach therapeutic concentrations in the aqueous humor.

代謝

Hepatic (for the small fraction that is systemically absorbed).

排除

Renal (for systemically absorbed drug).

過量

Topical overdose is unlikely to cause systemic toxicity due to the small volume administered. Ocular overdosage may lead to increased local irritation, hyperemia, and delayed corneal healing. If significant overexposure occurs, flush the eye with sterile saline.

可用產品

劑型

  • Ophthalmic: 0.03% solution in single-use vials

人用標示

  • Ocufen 0.03% eye drops (single-use vials)
  • Ocufen 0.03% ophthalmic solution (single-use vials)

各地核准狀態

United States✓ 已核准處方藥FDA
human

Used off-label in veterinary ophthalmology.

European Union✓ 已核准處方藥EMA

POM (Prescription Only Medicine)

United Kingdom✓ 已核准處方藥VMD

POM (Prescription Only Medicine)

暫無法規資料: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Store at room temperature (15-25°C). Protect from light. Single-use vials do not contain preservatives and should be discarded immediately after use.

飼主須知

請嚴格按照獸醫的處方點眼藥水。請勿讓滴管尖端接觸眼睛、眼瞼或任何其他表面，以防污染。若需使用多種眼藥，請至少間隔 5 分鐘。如果寵物的眼睛變得更紅、疼痛、混濁，或者開始瞇眼或揉眼睛，請立即聯繫您的獸醫。

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