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釓噴酸

Gadopentetic acid

放射線造影劑 - MRI造影劑IVIntra-articular狗

別名: Magnevist · Gadopentetate dimeglumine

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

0.1 mmol/kgIV· single dose· Repeat doses up to 0.3 mmol/kg total may be helpful in some cases
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劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。

各物種劑量

🌎 NA — North America🌍 EU — Europe

狗

適應症劑量途徑頻次療程地區
MRI examination (CNS, whole body)0.1 mmol/kgIVsingle doseRepeat doses up to 0.3 mmol/kg total may be helpful in some cases🌍 EU
  • MRI examination (CNS, whole body): Give as bolus if performing MRA, dynamic contrast or liver studies. Enhancement visible up to 45-60 minutes post-administration.

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概覽

釓噴酸是一種線性離子型順磁性釓螯合物，用作磁共振造影 (MRI) 的對比劑。用於識別異常血管化區域、勾勒腫塊輪廓，並顯示血腦屏障的破壞和發炎區域。

作用機制

Gadolinium is a paramagnetic agent that exerts its effects due to seven unpaired electrons → causes a shortening of T1 and T2 relaxation times of adjacent tissues → results in increased signal intensity on T1-weighted MR images.

安全性與警告

禁忌症

  • Severe renal impairment

不良反應

  • Nephrogenic systemic fibrosis (reported in humans)
  • Prolonged QT interval
  • Arrhythmias
  • Tissue irritation and necrosis if extravasated
  • Anaphylaxis (rare, 0.001%-0.01% in humans)
  • Transient increase in serum bilirubin

注意事項

​Warning:​ Hyper-osmolar and irritant if extravasation occurs; must be administered through an intravenous catheter. Use with caution in cardiac disease, pre-existing renal disease, and neonates. May cause false alterations in serum iron determination using complexometric methods.

藥物相互作用

Class 1a antiarrhythmicsModerate

Potential interaction affecting cardiac rhythm

Class 3 antiarrhythmicsModerate

Potential interaction affecting cardiac rhythm

監測

  • Cardiac rhythm (in case of overdose)
  • Renal function

藥物動力學

吸收

Administered intravenously or intra-articularly.

分佈

Does not cross the normal blood-brain barrier due to large molecular size. Protein binding is 0%.

代謝

Remains chelated.

排除

Renal excretion.

過量

Accidental overdosage may lead to an increase in QT interval and other arrhythmias. Cardiac monitoring is recommended in the event of an overdose.

可用產品

劑型

  • 469 mg/ml injection
  • 2 mmol/l injection (intra-articular)

人用標示

  • Magnevist 469 mg/ml vials and pre-filled syringes
  • Magnevist 2 mmol/l vials

各地核准狀態

European Union✗ 未核准處方藥 · POMEMA

None of the gadolinium chelates are authorized for veterinary use and all are POM.

United Kingdom✗ 未核准處方藥 · POMVMD

None of the gadolinium chelates are authorized for veterinary use and all are POM.

暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Store according to manufacturer guidelines.

飼主須知

這是一種在 ​MRI 掃描​ 期間使用的造影劑，可幫助您的獸醫更清楚地看到異常組織、血管或發炎。它直接經由靜脈注射。副作用很少見，但可能包括注射部位的輕微刺激或過敏反應。

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