牛血紅蛋白聚合物-200
**牛血紅蛋白聚合物-200** 是一種半合成的聚合牛血紅蛋白產品，在獸醫學中主要用作攜氧輸液和強效膠體。 * **主要適應症**：當無法取得全血或紅血球濃縮液，或交叉配血找不到合適捐血者時，用於治療貧血（由溶血、失血或紅血球生成無效引起）。 * **臨床要點**：在再生性貧血和緊急創傷情況下特別有價值。由於它不含基質且沒有紅血球膜，因此在給藥前不需要進行血型鑑定或交叉配血。 * **標示外使用**：曾用於貓以及患有新生畜同種紅血球溶解症的馬駒，但由於其強效的膠體特性，必須極度謹慎使用。
作用機制: HG-200 functions both as an oxygen carrier and a potent colloid expander: * **Oxygen Delivery**: Releases oxygen to tissues similarly to endogenous hemoglobin. It **shifts the oxygen dissociation curve to the right**, facilitating easier oxygen offloading to hypoxic tissues. * **Microvascular Perfusion**: Due to its small molecular size compared to intact RBCs, it can bypass severe arterial constrictions to oxygenate ischemic cells. * **Colloidal Effect**: Acts as a potent colloid (similar to dextran 70 or hetastarch), expanding intravascular volume by increasing oncotic pressure. * **Vascular Tone**: Causes significant **vasoconstriction**, which can increase blood pressure but may decrease cardiac output in hypovolemic states.
各物種劑量
- As an option to provide oxygen carrying capacity in the trauma patient · 2.5-10 mL/kg · IV · Given over several hours · Care must be taken not to cause fluid overload especially in cats.
- Labeled indications (anemia) · 10-30 mL/kg · IV · One-time dose at a rate of up to 10 mL/kg/hr · Do not administer with other fluids or drugs via the same infusion set.
- Resuscitation of trauma patients in shock with or without hemorrhage · 3-5 mL/kg · IV · Once · With concurrent crystalloid at 1/2 to 2 times maintenance.
- To provide a 'bridge' until immunosuppressive drugs take effect in dogs with IMHA with a transfusion reaction · 7-10 mL/kg or 30 mL/kg · IV · q12h (for 7-10 mL/kg dose) · 48-72 hours (for 30 mL/kg dose) · 7-10 mL/kg maintains Hb >3.5 g/dL; 30 mL/kg provides support for 48-72h.
- As an option to provide oxygen carrying capacity in the trauma patient · 10-15 mL/kg · IV · Given over several hours · Care must be taken not to cause fluid overload.
- As a vasopressor once there is adequate intravascular volume in trauma patients · 3-5 mL/kg · IV · Once
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
給藥途徑
禁忌症
- Advanced cardiac disease (e.g., congestive heart failure)
- Severely impaired cardiac function
- Renal impairment with oliguria or anuria
不良反應
- Discolored mucous membranes, sclera, skin (yellow, red, brown)
- Discolored urine (orange, red, brown)
- Increased central venous pressure (CVP)
- Ventricular arrhythmias (AV block, tachycardia, VPCs)
- Vomiting, diarrhea, anorexia
- Tachypnea, dyspnea, harsh lung sounds
- Pulmonary edema and pleural effusion (due to volume overload)
- Fever
- Peripheral edema
- Hemoglobinuria
監測
- Hemoglobin levels
- Clinical signs of adequate tissue oxygenation
- Central venous pressure (CVP) and signs of circulatory overload
- Respiratory rate and effort (watch for pulmonary edema)
- Heart rate and rhythm (watch for arrhythmias)
過量
Clinical signs of overdosage (1 to 3 times the recommended dose) include yellow-orange discoloration of skin, mucous membranes, and sclera; red-dark-green-black feces; brown-black urine; decreased appetite/thirst; vomiting; diarrhea; and decreased skin elasticity. Overdosage or excessively rapid administration (>10 mL/kg/hr) may result in severe circulatory overload (pulmonary edema, pleural effusion).
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。