牛血紅蛋白聚合物-200
Hemoglobin glutamer-200 (bovine)
Polymerized bovine hemoglobin
別名: Oxyglobin · HBOC-301 · HG-200 · Hemoglobin glutamer-200 · Hb200
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
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各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Labeled indications (anemia) | 10-30 mL/kg | IV | One-time dose at a rate of up to 10 mL/kg/hr | — | 🌎 NA |
| Resuscitation of trauma patients in shock with or without hemorrhage | 3-5 mL/kg | IV | Once | — | 🌎 NA |
| To provide a 'bridge' until immunosuppressive drugs take effect in dogs with IMHA with a transfusion reaction | 7-10 mL/kg or 30 mL/kg | IV | q12h (for 7-10 mL/kg dose) | 48-72 hours (for 30 mL/kg dose) | 🌎 NA |
| As an option to provide oxygen carrying capacity in the trauma patient | 10-15 mL/kg | IV | Given over several hours | — | 🌎 NA |
| As a vasopressor once there is adequate intravascular volume in trauma patients | 3-5 mL/kg | IV | Once | — | 🌎 NA |
- Labeled indications (anemia): Do not administer with other fluids or drugs via the same infusion set.
- Resuscitation of trauma patients in shock with or without hemorrhage: With concurrent crystalloid at 1/2 to 2 times maintenance.
- To provide a 'bridge' until immunosuppressive drugs take effect in dogs with IMHA with a transfusion reaction: 7-10 mL/kg maintains Hb >3.5 g/dL; 30 mL/kg provides support for 48-72h.
- As an option to provide oxygen carrying capacity in the trauma patient: Care must be taken not to cause fluid overload.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| As an option to provide oxygen carrying capacity in the trauma patient | 2.5-10 mL/kg | IV | Given over several hours | — | 🌎 NA |
- As an option to provide oxygen carrying capacity in the trauma patient: Care must be taken not to cause fluid overload especially in cats.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
牛血紅蛋白聚合物-200 是一種半合成的聚合牛血紅蛋白產品，在獸醫學中主要用作攜氧輸液和強效膠體。
- 主要適應症：當無法取得全血或紅血球濃縮液，或交叉配血找不到合適捐血者時，用於治療貧血（由溶血、失血或紅血球生成無效引起）。
- 臨床要點：在再生性貧血和緊急創傷情況下特別有價值。由於它不含基質且沒有紅血球膜，因此在給藥前不需要進行血型鑑定或交叉配血。
- 標示外使用：曾用於貓以及患有新生畜同種紅血球溶解症的馬駒，但由於其強效的膠體特性，必須極度謹慎使用。
作用機制
HG-200 functions both as an oxygen carrier and a potent colloid expander:
- Oxygen Delivery: Releases oxygen to tissues similarly to endogenous hemoglobin. It shifts the oxygen dissociation curve to the right, facilitating easier oxygen offloading to hypoxic tissues.
- Microvascular Perfusion: Due to its small molecular size compared to intact RBCs, it can bypass severe arterial constrictions to oxygenate ischemic cells.
- Colloidal Effect: Acts as a potent colloid (similar to dextran 70 or hetastarch), expanding intravascular volume by increasing oncotic pressure.
- Vascular Tone: Causes significant vasoconstriction, which can increase blood pressure but may decrease cardiac output in hypovolemic states.
安全性與警告
禁忌症
- Advanced cardiac disease (e.g., congestive heart failure)
- Severely impaired cardiac function
- Renal impairment with oliguria or anuria
不良反應
- Discolored mucous membranes, sclera, skin (yellow, red, brown)
- Discolored urine (orange, red, brown)
- Increased central venous pressure (CVP)
- Ventricular arrhythmias (AV block, tachycardia, VPCs)
- Vomiting, diarrhea, anorexia
- Tachypnea, dyspnea, harsh lung sounds
- Pulmonary edema and pleural effusion (due to volume overload)
- Fever
- Peripheral edema
- Hemoglobinuria
注意事項
HG-200 is a potent colloid and can cause severe vasoconstriction. Extreme care must be taken to avoid volume overload, which can lead to increased hydrostatic pressure, pulmonary edema, and pleural effusion (particularly important in cats). The volume required for fluid resuscitation is approximately 1/3 that of hetastarch. May cause immunologic reactions (IgG antibodies), though anaphylaxis is rare. Laboratory Interference: HG-200 severely impacts colorimetric laboratory tests, optical coagulation assays, and urine dipsticks. PCV and RBC counts are inaccurate measures of anemia for 24 hours post-administration due to dilutional effects.
監測
- Hemoglobin levels
- Clinical signs of adequate tissue oxygenation
- Central venous pressure (CVP) and signs of circulatory overload
- Respiratory rate and effort (watch for pulmonary edema)
- Heart rate and rhythm (watch for arrhythmias)
藥物動力學
半衰期
吸收
Administered intravenously. Peak plasma hemoglobin concentrations increase dose-dependently (e.g., ~2.5 g/dL at 15 mL/kg).
分佈
Remains primarily in the intravascular space where it acts as a potent colloid. Duration of effect continues for at least 24 hours.
代謝
Metabolized and eliminated by the reticuloendothelial system, similar to endogenous hemoglobin.
排除
Small amounts of unstabilized hemoglobin (<5%) may be excreted through the kidneys, causing red discoloration of the urine. Detectable in plasma for 5-7 days.
過量
Clinical signs of overdosage (1 to 3 times the recommended dose) include yellow-orange discoloration of skin, mucous membranes, and sclera; red-dark-green-black feces; brown-black urine; decreased appetite/thirst; vomiting; diarrhea; and decreased skin elasticity. Overdosage or excessively rapid administration (>10 mL/kg/hr) may result in severe circulatory overload (pulmonary edema, pleural effusion).
可用產品
劑型
- Intravenous infusion bags (60 mL, 125 mL)
獸醫用
- Hemoglobin Glutamer-200 (bovine) 13 g/dL in 60 mL and 125 mL ready-to-use infusion bags (Oxyglobin)
各地核准狀態
暫無法規資料: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store at room temperature or refrigerated (2°-30°C) for up to 3 years. Do not freeze. Must remain in its foil overwrap during storage to protect the hemoglobin from converting to methemoglobin. Once removed from the overwrap, it should be used within 24 hours.
飼主須知
重要提示：此藥物是一種暫時性的「血液替代品」，用於無法取得真實血液或血液不相容的危及生命緊急情況。
- 變色是正常現象：您寵物的牙齦、皮膚、眼睛和尿液可能會變成黃色、橙色、紅色或棕色。這是藥物的無害副作用，幾天後就會消退。
- 注意呼吸問題：因為這種輸液會將水分拉入血管中，可能會導致肺部積水。如果您的寵物呼吸急促、咳嗽或似乎呼吸困難，請立即聯繫您的獸醫。
- 費用與風險：這是一種重症加護藥物，具有顯著的費用和潛在風險。您的獸醫會在給藥前與您討論風險與效益的比例。
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