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洛替拉納

Lotilaner

體外寄生蟲驅殺藥 (異噁唑啉類)PO狗貓

別名: Credelio

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

1 tablet of appropriate size (56.25 mg, 112.5 mg, 225 mg, 450 mg, or 900 mg) based on body weightPO· monthly· Ongoing
56.25 mg — 每隻動物的固定劑量（不按體重換算）

劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。

各物種劑量

🌎 NA — North America🌍 EU — Europe

狗

適應症劑量途徑頻次療程地區
Parasite control (fleas and ticks)1 tablet of appropriate size (56.25 mg, 112.5 mg, 225 mg, 450 mg, or 900 mg) based on body weightPOmonthlyOngoing🌍 EU
  • Parasite control (fleas and ticks): Administer with food or within 30 minutes of feeding.

貓

適應症劑量途徑頻次療程地區
Parasite control (fleas and ticks)1 tablet of appropriate size (12 mg or 48 mg) based on body weightPOmonthlyOngoing🌍 EU
  • Parasite control (fleas and ticks): Administer with food or within 30 minutes of feeding.

劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。

正在為病患診症？VetSheet 的 AI 會把藥物、劑量與療程直接寫入結構化診症筆記。了解 VetSheet 如何運作

概覽

洛替拉納是一種屬於異噁唑啉類的全身性體外寄生蟲驅殺藥，用於治療和預防犬貓的跳蚤和壁蝨感染。

​臨床提示：​ 異噁唑啉類藥物非常有效且起效迅速，但寄生蟲必須附著並開始吸血才能接觸到有效成分。

作用機制

Lotilaner acts as an antagonist at gamma-aminobutyric acid (GABA)-gated chloride channels and, to a lesser extent, glutamate-gated chloride channels (GluCls) in insects and acarines.

Binding blocks the transfer of chloride ions across cell membranes → uncontrolled neuromuscular activity → paralysis → death of the parasite.

安全性與警告

禁忌症

  • Hypersensitivity to the active substance
  • Puppies less than 8 weeks of age or weighing less than 1.3 kg (dog product)
  • Kittens less than 8 weeks of age or weighing less than 0.5 kg (cat product)

不良反應

  • Vomiting
  • Diarrhea
  • Lethargy
  • Anorexia
  • Neurological signs (tremors, ataxia, seizures) - rare

注意事項

Use with caution in dogs and cats with a history of seizures or neurologic disorders. Must be administered with food or within 30 minutes of feeding for optimal absorption.

監測

  • Clinical efficacy (absence of fleas and ticks)
  • Adverse neurological signs (rare)

藥物動力學

半衰期

貓~4 weeks狗~30.7 days

吸收

Rapidly absorbed when administered with food. Peak plasma concentration is reached within 2 hours in dogs and 4 hours in cats.

分佈

Highly protein bound (>99%).

代謝

Minimal hepatic metabolism.

排除

Primarily excreted unchanged in feces via biliary excretion; minor renal excretion.

過量

Lotilaner is generally well tolerated even at multiple times the maximum recommended dose. Overdose may cause mild, transient gastrointestinal signs such as vomiting or diarrhea. Treatment is symptomatic and supportive.

可用產品

劑型

  • Oral chewable tablets

獸醫用

  • Credelio chewable tablets for dogs (56.25 mg, 112.5 mg, 225 mg, 450 mg, 900 mg)
  • Credelio chewable tablets for cats (12 mg, 48 mg)

各地核准狀態

United States✓ 已核准處方藥FDA/CVM
🐕 Dogs🐈 Cats
European Union✓ 已核准處方藥EMA
🐕 Dogs🐈 Cats

POM-V

United Kingdom✓ 已核准處方藥VMD
🐕 Dogs🐈 Cats

POM-V

暫無法規資料: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Store at room temperature (15-25°C). Keep out of reach of children and animals.

飼主須知

每月一次​隨餐​或在餵食後30分鐘內給予咀嚼錠，以確保藥物被妥善吸收。此藥物能殺死跳蚤和壁蝨，但牠們必須叮咬寵物才會接觸到藥物。

如果您的寵物出現嘔吐、腹瀉、嗜睡或任何異常的肌肉顫抖或癲癇發作，請聯繫您的獸醫師。

VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用，不能取代專業判斷或廠方最新藥品說明書。