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聚乙二醇 / 巨球經

Macrogol / Polyethylene glycol

Polyethylene glycol

滲透性瀉藥PO

別名: Klean-Prep · Moviprep · PEG · Polyethylene glycol · Macrogol 3350 · Macrogol 4000

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

各物種劑量

此藥的劑量資料尚未收錄於 VetSheet 藥典，以下其他章節資料完整。處方前請參閱最新藥品說明書。

概覽

含有​聚乙二醇 (Macrogol)​ 的腸道清潔液作為滲透性瀉藥。它們配有平衡的電解質以維持等滲透壓，防止在腸道準備過程中發生淨水分流失或增加。口服後能迅速排空腸道。

​臨床提示：​ 主要用於結腸鏡檢查、胃腸道X光檢查或手術前的腸道準備，偶爾也用於處理嚴重的頑固性便秘或糞便嵌塞。

作用機制

Polyethylene glycol acts as an osmotic laxative. It is a large, non-absorbable polymer that binds water → retains fluid within the colonic lumen → increases fecal volume and softens stool → stimulates colonic motility and peristalsis → rapidly empties the bowel. The addition of balanced electrolytes ensures isotonicity, preventing significant shifts of sodium, potassium, or water across the intestinal mucosa.

安全性與警告

禁忌症

  • Gastrointestinal obstruction
  • Bowel perforation
  • Gastric retention
  • Toxic megacolon
  • Severe dehydration

不良反應

  • Nausea
  • Vomiting
  • Abdominal cramping
  • Bloating
  • Fluid and electrolyte imbalances (rare if formulated with electrolytes)

注意事項

Use with caution in patients with an impaired gag reflex or those at risk of aspiration. Ensure the patient is adequately hydrated before administration. Do not add flavorings or other substances to the reconstituted solution as it may alter the osmolarity.

藥物相互作用

Oral medicationsModerate

Decreased absorption due to rapid gastrointestinal transit time

監測

  • Fecal output and consistency
  • Hydration status
  • Serum electrolytes (in prolonged or high-dose use)

藥物動力學

吸收

Minimal to no systemic absorption following oral administration.

分佈

Remains locally in the gastrointestinal tract.

代謝

Not metabolized.

排除

Excreted unchanged in the feces.

過量

Overdosage may result in severe diarrhea, leading to significant fluid and electrolyte loss. Treatment is primarily supportive, focusing on intravenous fluid therapy to restore hydration and correct any electrolyte derangements.

可用產品

劑型

  • Oral powder for reconstitution

人用標示

  • Klean-Prep powder for reconstitution
  • Moviprep powder for reconstitution

各地核准狀態

United States✓ 已核准處方藥FDA

Human-approved products used off-label in veterinary medicine.

European Union✓ 已核准處方藥EMA

Human-approved products used off-label.

United Kingdom✓ 已核准VMD

Available as a Pharmacy (P) medicine for humans, but veterinary use typically requires a prescription under the cascade.

暫無法規資料: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Store unmixed powder at room temperature. Once reconstituted with water, store the solution in the refrigerator and discard any unused portion after 24 to 48 hours (check specific manufacturer guidelines).

飼主須知

請嚴格按照指示將粉末與適量的水混合。不要添加任何調味料或與食物混合。請讓您的寵物有足夠的機會前往合適的地方排便，因為此藥物會引起快速且水狀的糞便。除非獸醫另有指示，否則請確保您的寵物隨時有新鮮的飲用水。

VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用，不能取代專業判斷或廠方最新藥品說明書。