麥角林 / 麥角靈
Metergoline
Benzyl (8S,10S)-(1,6-dimethylergolin-8-ylmethyl)carbamate
別名: Contralac · Liserdol · FI-6337 · MCE · Metergoliini · Metergolina · Métergoline · Metergolinum · Methergoline
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Treatment of pseudopregnancy | 0.5 mg/kg (500 micrograms/kg) PO twice a day | PO | q12h | 4-5 days | 🌎 NA |
| Treatment of pseudopregnancy | 0.1 mg/kg, PO twice a day | PO | q12h | 8 to 10 days | 🌎 NA |
| Treatment of pseudopregnancy | 0.1 mg/kg q12h PO with food | PO | q12h | 10 days | 🌎 NA |
| To induce estrus | 0.1 mg/kg PO twice a day | PO | q12h | From 100 days after ovulation until the following proestrus | 🌎 NA |
- Treatment of pseudopregnancy: Occasional failures can be dealt with by repeating the treatment protocol and extending it to 8 to 10 days, or by using joint protocols of cabergoline plus metergoline or cabergoline plus bromocriptine.
- Treatment of pseudopregnancy: Side effects were limited to hyperexcitation and nausea, did not lead to termination of therapy, and gradually dissipated during the second week.
- To induce estrus: Results have been variable depending on dosage. Can significantly shorten the interoestrous interval.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Treatment of pseudopregnancy or to halt post-partum lactation | 0.125 mg/kg PO twice a day | PO | q12h | 4-8 days | 🌎 NA |
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
麥角林 (Metergoline) 是一種麥角衍生物，在獸醫學中主要用於治療犬隻的假懷孕 (pseudopregnancy)。
主要臨床重點：
- 作為泌乳素抑制劑，可停止與假懷孕相關的不必要泌乳及行為改變。
- 曾被研究於妊娠最後3週以高劑量作為墮胎藥使用。
- 在美國無商業化產品，但在歐洲和南美洲廣泛使用。
- 在人類醫學中，用於治療高泌乳素血症及預防偏頭痛。
作用機制
Metergoline reduces prolactin secretion primarily through its serotonin receptor antagonism.
Mechanistic pathway:
- Serotonin (5-HT) antagonism → Inhibition of prolactin release from the anterior pituitary.
- Unlike other prolactin inhibitors (e.g., cabergoline, bromocriptine), it possesses strong central and peripheral anti-serotonin effects.
- Exhibits weak direct dopamine-2 (D2) agonist effects and acts as an antagonist at dopamine-1 (D1) receptors.
安全性與警告
禁忌症
- Pregnancy (unless abortion is desired)
- Nursing mothers
- Hypersensitivity to ergot derivatives
不良反應
- Anxiety
- Aggressiveness
- Depression
- Hyperexcitation
- Whining
- Escaping behavior
- Anorexia
- Vomiting
- Nausea
注意事項
Use with caution in patients with significantly impaired liver function; a lower dosage may be required. Patients that do not tolerate cabergoline or bromocriptine may or may not tolerate metergoline. Do not use in pregnant animals unless pregnancy termination is the specific clinical goal.
藥物相互作用
May cause additive effects if used with metergoline
May cause additive effects if used with metergoline
May cause additive effects if used with metergoline
Use with metergoline may reduce the efficacy of both drugs and should be avoided
Potentially could reduce the efficacy of each drug
監測
- Clinical efficacy (resolution of pseudopregnancy signs)
- Adverse behavioral or GI effects
- Liver function tests (if used long-term)
藥物動力學
半衰期
吸收
In humans, oral bioavailability is about 25%.
分佈
In humans, volume of distribution is 0.8 L/kg.
代謝
Metabolized in the liver to at least one active metabolite (1-desmethylmetergoline) which attains plasma levels higher than that of the parent drug.
排除
In humans, elimination half-life of the parent drug is about 50 minutes; 1-desmethylmetergoline is 80-100 minutes.
過量
Little information is available regarding acute toxicity. Vomiting is the most likely clinical sign expected in an overdose situation. Treatment should be supportive and symptomatic.
可用產品
劑型
- Oral tablets
獸醫用
- Metergoline 0.5 mg oral tablets
- Metergoline 2 mg oral tablets
人用標示
- Metergoline 4 mg tablets
各地核准狀態
暫無法規資料: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Metergoline tablets should be stored at room temperature; protected from light.
飼主須知
重要提示： 請將此藥物與食物一起餵食，以減少腸胃不適。
- 注意副作用： 您的寵物可能會出現噁心、嘔吐或行為改變（如焦慮、哀鳴或逃跑行為）。如果嘔吐持續或行為改變嚴重，請聯繫您的獸醫師。
- 請勿用於懷孕寵物： 此藥物可能導致流產。
- 請將此藥物及所有藥物妥善存放在兒童和其他寵物接觸不到的地方。
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