分枝桿菌細胞壁萃取免疫調節劑
Mycobacterial Cell Wall Fraction Immunomodulator
Mycobacterial cell wall extract
別名: Regressin-V · Equimune I.V. · Settle · Mycobacterial cell wall extract · Bacillus Calmette-Guerin · BCG
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Immunotherapy of mixed mammary tumor and mammary adenocarcinoma | Dosage varies with tumor size, but 1 mL should be considered a minimum dose. Infiltrate entire tumor and a small region of adjacent and underlying tissue. | Intratumoral | Once, 2-4 weeks before surgery. If surgery is not to be used, repeat treatment every 1-3 weeks. | Discontinue if no response after 4 treatments | 🌎 NA |
- Immunotherapy of mixed mammary tumor and mammary adenocarcinoma: Using no larger than a 20-gauge needle. Be certain the emulsion is mixed thoroughly and inject quickly as emulsion can separate rapidly. Additional anesthetics or analgesics may be used for pain.
馬
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Immunotherapy of sarcoids | Dosage varies with tumor size, but 1 mL should be considered a minimum dose. Infiltrate entire tumor and a small region of adjacent and underlying tissue. | Intratumoral | Repeat treatment every 1-3 weeks. | Discontinue if no response after 4 treatments | 🌎 NA |
| Immunotherapeutic agent for the treatment of Equine Respiratory Disease Complex (ERDC) | 1.5 mL (one syringe) | IV | May be repeated in 1-3 weeks | — | 🌎 NA |
| Aid in the treatment of equine metritis caused by Streptococcus zooepidemicus | 1.5 mL (one syringe) | IV | Once during the early estrus period | — | 🌎 NA |
| Aid in the treatment of equine metritis caused by Streptococcus zooepidemicus | Dilute 1.5 mL of Settle in sterile LRS, normal saline, water for injection or semen extender to provide a final volume of 25-50 mL. | Intrauterine | Once | — | 🌎 NA |
- Immunotherapy of sarcoids: Large pedunculated sarcoids should be de-bulked by partial excision prior to treatment. Use no larger than a 20-gauge needle. Inject quickly as emulsion separates rapidly.
- Immunotherapeutic agent for the treatment of Equine Respiratory Disease Complex (ERDC): Inject into the jugular vein.
- Aid in the treatment of equine metritis caused by Streptococcus zooepidemicus: Inject into the jugular vein.
- Aid in the treatment of equine metritis caused by Streptococcus zooepidemicus: Aseptically administer the diluted solution into the uterus using a sterile catheter.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
分枝桿菌細胞壁萃取免疫調節劑 是一種生物製劑，在獸醫學中主要用於刺激患病動物的免疫系統以對抗腫瘤和特定感染。
- 在狗中，它被用作局部浸潤注射，用於混合性乳腺瘤和乳腺腺癌的免疫療法。
- 在馬中，它用於治療馬肉樣瘤（局部浸潤）、透過靜脈注射治療馬呼吸道疾病綜合徵 (ERDC)，以及由獸疫鏈琊菌 (Streptococcus zooepidemicus) 引起的馬子宮內膜炎（靜脈注射或子宮內灌注）。
臨床提示： 由於這是一種免疫調節劑，其療效完全依賴於患者具備功能正常的免疫系統。雖然局部（腫瘤內）的療效已有文獻記載，但全身性療效尚未得到充分證實。
作用機制
The drug exerts a non-specific immune stimulatory effect, primarily targeting cell-mediated immune mechanisms and macrophage activation.
- Macrophage activation → Release of Interleukin-1 (IL-1) → Cascade of immune responses targeting abnormal cells (tumors) or pathogens.
- Requires a competent, functional immune system to be effective.
安全性與警告
禁忌症
- Prior hypersensitivity to mycobacterial cell wall compounds
- Active mycobacterial infections
不良反應
- Transient fever
- Depression or drowsiness
- Decreased appetite
- Localized pain and tenderness at injection site
- Tumor necrosis and draining (expected therapeutic effect but can be an adverse event)
- Hypersensitivity or Anaphylaxis
- Severe respiratory inflammatory reactions (reported in horses)
注意事項
Patients receiving cortisone or ACTH may not respond to treatment due to immunosuppression. In case of an anaphylactic reaction, administer epinephrine. The emulsion separates rapidly and must be thoroughly mixed/re-emulsified immediately before administration.
藥物相互作用
May reduce the effectiveness of mycobacterial cell wall immunostimulants
監測
- Clinical Efficacy (tumor size, metritis improvement, or respiratory infection improvement)
- Adverse Effects (fever, local reactions, appetite)
藥物動力學
吸收
No information was located.
分佈
No information was located.
代謝
No information was located.
排除
No information was located.
過量
No information was located regarding overdosage or acute toxicity.
可用產品
劑型
- Injection (intratumoral, IV, intrauterine)
獸醫用
- Equimune I.V.: 1.5 mL single use vials and 4.5 mL multi-dose vials (Labeled for horses)
- Settle: 1.5 mL single use vials (Contains gentamicin as a preservative. Labeled for horses)
- Regressin-V: 10 mL vials (Contains procaine and a green dye. Labeled for horses and dogs)
各地核准狀態
暫無法規資料: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store refrigerated (2-7°C), but do not freeze. Unused product from single-use vials should be discarded after use. The emulsion 'breaks' upon standing and must be re-emulsified before administration. To re-emulsify to a milky appearance, shake vial, roll syringe between hands, or heat in hot water (150°F, 65°C).
飼主須知
- 注射部位反應： 腫瘤內注射可能會引起注射部位的疼痛或觸痛。
- 腫瘤變化： 腫瘤可能會排液或出現壞死（組織死亡）。 > 注意： 這表示治療正在發揮作用！如果發生這種情況且造成困擾，請聯絡您的獸醫師以獲得進一步的處理指示。
- 全身性症狀： 接受治療的動物在治療後的幾天內可能會出現抑鬱、發燒或食慾減退。如果這些症狀持續超過 1-2 天或變得嚴重，請聯絡您的獸醫師。
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