奧曲肽
奧曲肽是一種**體抑素類似物**，在獸醫學中主要用於控制胰腺內分泌腫瘤（如**胰島素瘤**、**胃泌素瘤**）和**肢端肥大症**。 > **臨床警告**：研究表明，奧曲肽對大多數胰島素瘤無效。不表達體抑素受體的腫瘤將不會對治療產生反應。 **臨床提示**：雖然奧曲肽已被用於治療肢端肥大症，但較新的體抑素類似物（如帕瑞肽 pasireotide）在治療上更具前景，儘管目前價格昂貴。
作用機制: Octreotide acts as a synthetic **somatostatin analogue**. It binds to **somatostatin receptors** (SSTRs) → inhibits the release of several hormones, including growth hormone (GH), insulin, glucagon, and gastrin, as well as reducing splanchnic blood flow and gastrointestinal motility.
各物種劑量
- Management of pancreatic endocrine tumours and acromegaly · 10-20 μg/animal or 10 μg/animal · SC · q8-12h or q8h · As directed · Dose is for the aqueous preparation. Dosages for the depot preparation are not known in animals.
- Management of pancreatic endocrine tumours and acromegaly · 10-20 μg/animal or 10 μg/animal · SC · q8-12h or q8h · As directed · Dose is for the aqueous preparation. Dosages for the depot preparation are not known in animals.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
給藥途徑
禁忌症
- Known hypersensitivity to octreotide
不良反應
- Anorexia
- Vomiting
- Abdominal pain
- Bloating
- Diarrhoea
- Steatorrhoea
- Hepatopathy
- Pain at injection sites
監測
- Blood glucose levels (especially when treating insulinoma)
- Clinical signs of gastrointestinal upset
- Liver enzymes (due to potential hepatopathy)
- Injection site reactions
過量
No specific information available in the monograph. Overdose may exacerbate gastrointestinal disturbances and cause significant fluctuations in blood glucose levels. Treatment should be symptomatic and supportive.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。