胰酶補充劑
Pancreatic enzyme supplements
Pancreatin / Pancrelipase
別名: Lypex · Panzym · Pro-Enzorb · Pancrelipase · Pancreatic enzymes
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Exocrine pancreatic insufficiency (EPI) | Use manufacturer's recommendations initially. Adjust to obtain normal faeces. Reduce gradually over 7 days to find minimally effective dose. | PO | with every meal | Lifelong | 🌍 EU |
- Exocrine pancreatic insufficiency (EPI): Lypex capsules must be opened and contents sprinkled in with food. Follow dosing with food or water.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Exocrine pancreatic insufficiency (EPI) | Use manufacturer's recommendations initially. Adjust to obtain normal faeces. Reduce gradually over 7 days to find minimally effective dose. | PO | with every meal | Lifelong | 🌍 EU |
- Exocrine pancreatic insufficiency (EPI): Lypex capsules must be opened and contents sprinkled in with food. Follow dosing with food or water.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
胰酶補充劑是外源性替代療法，用於控制胰外分泌功能不足 (EPI) 的臨床症狀。這些補充劑含有脂肪酶、蛋白酶和澱粉酶的混合物。
臨床提示： 併用維生素B12 (鈷胺素) 治療通常能顯著提升療效，因為 EPI 病患常伴隨低鈷胺素血症。同時給予制酸劑通常不具成本效益，且酵素在餵食前不需要與食物預先混合靜置。新鮮生豬胰臟或冷凍豬胰臟也是有效的替代方案，但取得不易且有病原體感染風險。
作用機制
Provides exogenous replacement of pancreatic enzymes:
- Lipase → hydrolyses dietary triglycerides into fatty acids and glycerol.
- Protease → cleaves peptide bonds to break down dietary proteins.
- Amylase → hydrolyses complex carbohydrates into simpler sugars. These actions restore digestive capability in the small intestine, facilitating nutrient absorption and resolving maldigestion.
安全性與警告
不良反應
- Contact dermatitis of the lips (with powdered non-coated enzymes)
- Offensive body/fecal odour
- Oral or oesophageal ulcers (with non-coated enzymes)
- Diarrhoea (at high doses)
- GI cramping (at high doses)
注意事項
Handler Safety: Powder spilled on hands should be washed off immediately to prevent skin irritation. Avoid inhaling powder as it causes mucous membrane irritation and may trigger asthma attacks in susceptible individuals. These risks are generally not associated with enteric-coated granules.
Patient Safety: Non-coated pancreatic enzymes may cause oral or oesophageal ulcers; dosing must always be followed with food or water.
藥物相互作用
May diminish the effectiveness of the pancreatic enzymes
監測
- Faecal consistency and volume
- Body weight and body condition score
- Serum cobalamin (Vitamin B12) and folate levels
藥物動力學
吸收
Enzymes act locally in the gastrointestinal tract and are not absorbed intact into the systemic circulation.
分佈
Confined to the gastrointestinal lumen.
代謝
Digested and degraded by other enzymes and bacteria in the lower gastrointestinal tract.
排除
Excreted in the faeces.
過量
High doses may cause diarrhoea and signs of gastrointestinal cramping. Reduce dose if these signs occur.
可用產品
劑型
- Oral powder (non-enteric-coated)
- Enteric-coated tablets
- Capsules (containing enteric-coated granules)
獸醫用
- Lypex (capsules)
- Pancreatic Enzyme for cats and dogs
- Panzym
- Pro-Enzorb
人用標示
- Creon
- Pancrex
各地核准狀態
Available as AVM-GSL in some regions
Classified as AVM-GSL (Authorised Veterinary Medicine - General Sales List)
暫無法規資料: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store in a cool, dry place. Keep containers tightly closed to protect from moisture.
飼主須知
給藥方式： 將處方劑量的粉末或膠囊內容物與寵物每一餐的食物徹底混合。不需要讓食物靜置發酵。確保寵物在進食後立即喝水或吃東西，以將酵素沖下，防止口腔潰瘍。
安全警告： 處理粉末後請洗手，以避免皮膚刺激。請勿吸入粉末，因為它會刺激呼吸道或引發氣喘。
預期效果： 這通常是終身治療。您的獸醫將根據寵物的糞便品質和體重增加情況，協助您找到最低的有效劑量。
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