胰酶補充劑
**胰酶補充劑**是外源性替代療法，用於控制**胰外分泌功能不足 (EPI)** 的臨床症狀。這些補充劑含有**脂肪酶、蛋白酶和澱粉酶**的混合物。 > **臨床提示：** 併用**維生素B12 (鈷胺素)** 治療通常能顯著提升療效，因為 EPI 病患常伴隨低鈷胺素血症。同時給予制酸劑通常不具成本效益，且酵素在餵食前不需要與食物預先混合靜置。新鮮生豬胰臟或冷凍豬胰臟也是有效的替代方案，但取得不易且有病原體感染風險。
作用機制: Provides exogenous replacement of pancreatic enzymes: * **Lipase** → hydrolyses dietary triglycerides into fatty acids and glycerol. * **Protease** → cleaves peptide bonds to break down dietary proteins. * **Amylase** → hydrolyses complex carbohydrates into simpler sugars. These actions restore digestive capability in the small intestine, facilitating nutrient absorption and resolving maldigestion.
各物種劑量
- Exocrine pancreatic insufficiency (EPI) · Use manufacturer's recommendations initially. Adjust to obtain normal faeces. Reduce gradually over 7 days to find minimally effective dose. · PO · with every meal · Lifelong · Lypex capsules must be opened and contents sprinkled in with food. Follow dosing with food or water.
- Exocrine pancreatic insufficiency (EPI) · Use manufacturer's recommendations initially. Adjust to obtain normal faeces. Reduce gradually over 7 days to find minimally effective dose. · PO · with every meal · Lifelong · Lypex capsules must be opened and contents sprinkled in with food. Follow dosing with food or water.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
給藥途徑
不良反應
- Contact dermatitis of the lips (with powdered non-coated enzymes)
- Offensive body/fecal odour
- Oral or oesophageal ulcers (with non-coated enzymes)
- Diarrhoea (at high doses)
- GI cramping (at high doses)
藥物相互作用
- Antacids (magnesium hydroxide, calcium carbonate) · May diminish the effectiveness of the pancreatic enzymes · moderate
監測
- Faecal consistency and volume
- Body weight and body condition score
- Serum cobalamin (Vitamin B12) and folate levels
過量
High doses may cause **diarrhoea** and signs of **gastrointestinal cramping**. Reduce dose if these signs occur.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。