多硫酸化糖胺聚醣
Polysulfated Glycosaminoglycan
Polysulfated glycosaminoglycan (PSGAG)
別名: Adequan · PSGAG
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Indolent corneal ulcers | 1 drop of a 5% PSGAG solution in artificial tears | topical ophthalmic | TID | — | 🌎 NA |
- Indolent corneal ulcers: Anecdotal efficacy
馬
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Indolent corneal ulcers | 1 drop of a 5% PSGAG solution in artificial tears | topical ophthalmic | TID | up to 3 weeks | 🌎 NA |
- Indolent corneal ulcers: 86% of eyes treated were considered healed within 3 weeks
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
最初開發用於退化性骨關節炎，但對角膜潰瘍管理具有潛在療效。據傳在促進狗和馬的無痛性角膜潰瘍癒合方面有效。
作用機制
Inhibits multiple degradative enzymes (lysozyme, hyaluronidase, and serine proteases) → decreases prostaglandin E2 synthesis → reduces production of toxic superoxide radicals → increases synthesis of collagen proteoglycans and hyaluronic acid.
安全性與警告
注意事項
Surgical keratectomy remains the most reliable treatment for indolent ulcers. Efficacy in dogs is currently anecdotal.
監測
- Corneal ulcer healing via fluorescein staining
可用產品
劑型
- Ophthalmic solution 5% (compounded from injectable)
獸醫用
- Adequan injection (diluted 1:1 with sterile artificial tears to produce a 5% PSGAG solution)
各地核准狀態
暫無法規資料: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store compounded ophthalmic solutions as directed by the compounding pharmacist, typically refrigerated.
飼主須知
請嚴格按照獸醫師的指示點眼藥水。觀察寵物的眼睛是否有發紅加劇、瞇眼或分泌物增多的跡象，若眼睛似乎更痛，請聯繫您的診所。
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