普羅孕酮
Proligestone
別名: Delvosteron · Proligestonum
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Suppression of oestrus | 10-33 mg/kg depending on body weight (<5kg: 100-150mg; 5-10kg: 150-250mg; 10-20kg: 250-350mg; 20-30kg: 350-450mg; 30-45kg: 450-550mg; 45-60kg: 550-600mg; >60kg: 10 mg/kg) | SC | Once | Single dose | 🌍 EU |
| Permanent postponement of oestrus | 10-33 mg/kg depending on body weight (see weight table) | SC | 1st dose before pro-oestrus, 2nd dose 3 months later, 3rd dose 4 months later, then every 5 months | Ongoing | 🌍 EU |
| Acromegaly | 10-33 mg/kg depending on body weight (see weight table) | SC | Monthly | Until signs of hair growth are evident | 🌍 EU |
- Suppression of oestrus: Given once for suppression. Inject into medial side of flank fold.
- Permanent postponement of oestrus: Once dosing ceases, bitches may come into oestrus on average 6-7 months later, but it may take up to 3 years in some cases.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Postponement of oestrus / Miliary dermatitis | Dose not explicitly specified in text; refer to manufacturer guidelines | SC | Not specified | Not specified | 🌍 EU |
- Postponement of oestrus / Miliary dermatitis: Authorized for miliary dermatitis, but specific glucocorticoids are preferred.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
普羅孕酮是一種合成的孕激素，在獸醫學中主要用於延遲或抑制母狗和母貓的發情期。它也被授權用於治療貓的粟粒性皮膚炎，儘管在這種適應症中通常更傾向於使用特定的糖皮質激素。
臨床警告：普羅孕酮具有長期使用孕激素的典型風險，包括可能引發囊性子宮內膜增生（子宮蓄膿）、糖尿病和乳腺腫瘤。應謹慎使用，且禁忌用於患有糖尿病的動物。
作用機制
Proligestone alters the transcription of DNA → leads to alterations in cellular metabolism → mimics the physiological effects caused by endogenous progesterone.
安全性與警告
禁忌症
- Diabetic animals (insulin requirements are likely to change unpredictably)
- Bitches before or at their first oestrus
不良反應
- Unpredictable duration of anoestrus (up to 3 years in some bitches)
- Temperament changes (listlessness and depression)
- Polyuria and polydipsia (increased thirst)
- Polyphagia (increased appetite)
- Cystic endometrial hyperplasia / Pyometra
- Diabetes mellitus
- Acromegaly
- Adrenocortical suppression
- Mammary enlargement, lactation, or neoplasia
- Injection site irritation
- Coat colour changes at the injection site
- Calcinosis circumscripta at the injection site
注意事項
As coat colour changes may occasionally occur, injection into the medial side of the flank fold is recommended for thin-skinned or show animals.
Clinical Pearl: While proligestone does not appear to be associated with as many or as serious adverse effects as older progestogens (e.g., megestrol acetate, medroxyprogesterone acetate), owners must still be thoroughly counseled on the risks of pyometra and diabetes mellitus.
監測
- Signs of pyometra (vaginal discharge, lethargy, polyuria/polydipsia)
- Blood glucose and clinical signs of diabetes mellitus (excessive thirst and urination)
- Mammary gland changes (enlargement, masses)
- Injection site reactions
藥物動力學
半衰期
吸收
Absorbed slowly from the subcutaneous injection site, providing a prolonged duration of effect.
分佈
Highly lipophilic; distributes widely into tissues.
代謝
Hepatic metabolism.
排除
Excreted primarily via feces and urine.
過量
No specific information provided in the monograph. Overdosage may increase the risk and severity of progestational side effects, including cystic endometrial hyperplasia, diabetes mellitus, and adrenocortical suppression. Treatment is supportive.
可用產品
劑型
- 100 mg/ml injectable suspension
獸醫用
- Delvosteron 100 mg/ml suspension for injection
各地核准狀態
Not commercially available in the US.
Authorized in various EU member states.
Prescription Only Medicine - Veterinarian.
暫無法規資料: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Normal precautions should be observed. Store in a cool, dry place away from direct sunlight. Shake well before use.
飼主須知
普羅孕酮是一種注射型荷爾蒙，用於延遲或停止寵物的發情週期。
- 恢復發情：停止注射後，您的狗通常需要6-7個月才會再次發情，但這非常難以預測，有時可能長達3年。
- 副作用：密切觀察是否出現口渴增加、排尿增加或食慾增加的情況。這些可能是糖尿病或嚴重的子宮感染（子宮蓄膿）的早期徵兆。
- 行為改變：您的寵物可能會比平時顯得更嗜睡或抑鬱。
- 注射部位：您可能會注意到注射部位的毛色改變或出現小腫塊。如果該區域發炎，請聯繫您的獸醫。
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