吡蟲普羅
抗寄生蟲藥 - 苯基吡唑類
吡蟲普羅是一種苯基吡唑類抗寄生蟲藥，用於**治療和預防狗的跳蚤感染**（犬櫛頭蚤、貓櫛頭蚤）以及**預防壁蝨**。以滴劑形式局部使用。 > **臨床警告：** 請勿用於貓。在懷孕和哺乳期母犬，或8週齡以下、體重低於2公斤的幼犬中，其安全性尚未確立。
作用機制: Pyriprole acts by interacting with **ligand-gated (GABA) chloride channels**, blocking the pre- and post-synaptic transfer of chloride ions → leading to hyperexcitation of the central nervous system and subsequent death of the parasites.
各物種劑量
Dogs
- Fleas and ticks · minimum dose 12.5 mg/kg · topical · q4wk · For large dogs, the 5 ml dose should be applied in 2-3 spots.
Cats
- Contraindicated · Do not use. · topical · Strictly contraindicated in cats.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
給藥途徑
Topical
禁忌症
- Cats
- Pregnant and lactating females (safety not established)
- Dogs < 8 weeks of age
- Dogs < 2 kg body weight
不良反應
- Pruritus/dermatitis at application site
- Lethargy
- Ataxia
- Convulsions
- Emesis
- Diarrhoea
監測
- Efficacy of flea and tick control
- Application site reactions
- Neurological signs (ataxia, convulsions)
過量
No specific information available in the monograph. Overdose may exacerbate known adverse reactions such as neurological signs (ataxia, convulsions) and gastrointestinal upset (emesis, diarrhoea). Treat symptomatically.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。