吡蟲普羅
Pyriprole
別名: Prac-tic
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Fleas and ticks | minimum dose 12.5 mg/kg | topical | q4wk | — | 🌍 EU |
- Fleas and ticks: For large dogs, the 5 ml dose should be applied in 2-3 spots.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Contraindicated | Do not use. | topical | — | — | 🌍 EU |
- Contraindicated: Strictly contraindicated in cats.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
吡蟲普羅是一種苯基吡唑類抗寄生蟲藥，用於治療和預防狗的跳蚤感染（犬櫛頭蚤、貓櫛頭蚤）以及預防壁蝨。以滴劑形式局部使用。
臨床警告： 請勿用於貓。在懷孕和哺乳期母犬，或8週齡以下、體重低於2公斤的幼犬中，其安全性尚未確立。
作用機制
Pyriprole acts by interacting with ligand-gated (GABA) chloride channels, blocking the pre- and post-synaptic transfer of chloride ions → leading to hyperexcitation of the central nervous system and subsequent death of the parasites.
安全性與警告
禁忌症
- Cats
- Pregnant and lactating females (safety not established)
- Dogs < 8 weeks of age
- Dogs < 2 kg body weight
不良反應
- Pruritus/dermatitis at application site
- Lethargy
- Ataxia
- Convulsions
- Emesis
- Diarrhoea
注意事項
Do not use on cats. Bathing is not recommended for 48 hours prior to and 24 hours after application. May be harmful to aquatic organisms; prevent access to watercourses. For large dogs, the 5 ml dose should be applied in 2-3 spots. For treatment of flea infestations, the additional use of an approved insect growth regulator is recommended.
監測
- Efficacy of flea and tick control
- Application site reactions
- Neurological signs (ataxia, convulsions)
過量
No specific information available in the monograph. Overdose may exacerbate known adverse reactions such as neurological signs (ataxia, convulsions) and gastrointestinal upset (emesis, diarrhoea). Treat symptomatically.
可用產品
劑型
- Topical: 125 mg/ml spot-on pipettes of various sizes
獸醫用
- Prac-tic 125 mg/ml spot-on pipettes
各地核准狀態
POM-V
POM-V
暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Normal precautions should be observed.
飼主須知
請按照指示將滴劑直接塗抹在狗的皮膚上。對於大型犬，請分2-3個不同部位塗抹。在用藥前48小時及用藥後24小時內，請勿給狗洗澡。
警告： 絕對不可將此產品用於貓。請讓接受治療的狗遠離池塘和溪流，因為該藥物對水生生物有毒。
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