沙羅拉納
Sarolaner
別名: Stronghold Plus · Simparica Trio · Sarolanerum
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
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各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Treatment of fleas, ticks, ear mites (Otodectes cynotis), demodicosis (Demodex canis), and Sarcoptes scabiei | 2-4 mg/kg | PO | monthly | Monthly (duration depends on parasite targeted) | 🌍 EU |
- Treatment of fleas, ticks, ear mites (Otodectes cynotis), demodicosis (Demodex canis), and Sarcoptes scabiei: Administer every month.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Treatment of fleas, ticks, ear mites, biting lice, adult roundworms, adult hookworms, and prevention of heartworm disease | 1 mg/kg sarolaner (with 6 mg/kg selamectin) | topical | monthly | Monthly | 🌍 EU |
- Treatment of fleas, ticks, ear mites, biting lice, adult roundworms, adult hookworms, and prevention of heartworm disease: Administer monthly using the combination spot-on product.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
沙羅拉納是一種異噁唑啉類抗寄生蟲藥，用於治療和預防犬貓的跳蚤、壁蝨和蟎蟲感染。它有犬用口服錠劑（Simparica）以及與色拉菌素（Selamectin）結合的貓用滴劑（Stronghold Plus）。
重要提示： 寄生蟲必須開始吸血才能接觸到藥物，因此無法完全排除傳染性媒介疾病的傳播。
臨床提示： 異噁唑啉類藥物因其高效和易用性，徹底改變了毛囊蟲症和疥癬蟲症的治療。然而，作為該類藥物的共同特性，對於有癲癇或神經系統疾病病史的動物應謹慎使用。
作用機制
Sarolaner acts at ligand-gated chloride channels, specifically those gated by the neurotransmitter gamma-aminobutyric acid (GABA) and glutamate.
Binding to these receptors → blocks pre- and post-synaptic transfer of chloride ions across cell membranes → causes uncontrolled neuromuscular activity → leads to the death of the parasite. It has highly selective toxicity for arthropods compared to mammals.
安全性與警告
禁忌症
- Dogs < 8 weeks of age
- Dogs < 1.3 kg body weight
- Cats < 8 weeks of age
- Cats < 1.25 kg body weight
- Known hypersensitivity to the active substance
不良反應
- Mild gastrointestinal signs (vomiting, diarrhea)
- Mild pruritus or alopecia at the site of application (spot-on product)
- Neurologic signs (tremors, ataxia, seizures) - rare class effect of isoxazolines
注意事項
Neurologic Warning: Use with caution in dogs and cats with a history of seizures or other neurologic disorders.
Normal safety and handling precautions should be observed. Wash hands after applying topical formulations.
藥物相互作用
Sarolaner is highly bound to plasma proteins and might compete with other highly bound drugs, potentially increasing free fractions.
Potential competition for plasma protein binding sites.
No interactions observed when co-administered.
No interactions observed when co-administered.
No interactions observed when co-administered.
監測
- Efficacy of parasite control
- Monitor for gastrointestinal upset after administration
- Monitor for neurological signs in susceptible individuals
藥物動力學
半衰期
吸收
Well absorbed following oral administration in dogs.
分佈
Highly bound to plasma proteins (>99%). Widely distributed to tissues.
代謝
Minimal hepatic metabolism.
排除
Primarily eliminated unchanged in feces via biliary excretion.
過量
Overdose may increase the risk of adverse effects, particularly gastrointestinal signs (vomiting, diarrhea) and potentially neurological signs (tremors, ataxia, seizures). Treatment is symptomatic and supportive as there is no specific antidote.
可用產品
劑型
- Oral tablets: 5 mg, 10 mg, 20 mg, 40 mg, 80 mg, 120 mg
- Topical spot-on solution (combination with selamectin for cats)
獸醫用
- Simparica 5 mg, 10 mg, 20 mg, 40 mg, 80 mg, 120 mg chewable tablets for dogs
- Stronghold Plus spot-on solution for cats (sarolaner + selamectin)
- Simparica Trio chewable tablets for dogs (sarolaner + moxidectin + pyrantel)
各地核准狀態
Available as Simparica, Simparica Trio, and Revolution Plus (selamectin/sarolaner).
POM-V classification.
POM-V classification.
暫無法規資料: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store in the original packaging at room temperature. Keep out of reach of children and animals.
飼主須知
請嚴格按照獸醫師的指示給藥。
- 口服錠劑（犬）： 可與食物一起或單獨餵食。請確保狗狗吃下完整的劑量。
- 滴劑（貓）： 將藥液滴在貓咪頸部基部、肩胛骨前方的皮膚上（貓咪舔不到的地方）。請勿搓揉。
重要提示： 壁蝨和跳蚤必須附著在寵物身上並開始吸血才會被藥物殺死。您可能仍會在寵物的毛髮上看到死亡或瀕死的壁蝨。如果您的寵物出現嘔吐、腹瀉、嗜睡或任何不協調的動作，請聯繫您的獸醫師。
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