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司可巴比妥與辛可卡因

Secobarbital and Cinchocaine

Secobarbital / Cinchocaine

安樂死藥物（巴比妥類/局部麻醉劑複方）IV狗貓

別名: Somulose · Quinalbarbitone/Cinchocaine · Secobarbital sodium/Cinchocaine hydrochloride

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

0.25 ml/kgIV· once· over 10-15 seconds
— 🐕

劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。

各物種劑量

🌎 NA — North America🌍 EU — Europe

狗

適應症劑量途徑頻次療程地區
Euthanasia0.25 ml/kgIVonceover 10-15 seconds🌍 EU
  • Euthanasia: Administer over 10-15 seconds to minimize premature cardiac arrest. IV catheter recommended.

貓

適應症劑量途徑頻次療程地區
Euthanasia0.25 ml/kgIVonceover 10-15 seconds🌍 EU
  • Euthanasia: Administer over 10-15 seconds to minimize premature cardiac arrest. IV catheter recommended.

劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。

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概覽

這是一種由巴比妥類藥物（司可巴比妥）和局部麻醉劑（辛可卡因）組成的強效複方安樂死藥物，專門用於犬貓的人道安樂死。​臨床警告：​ 此藥物對人類具有高度毒性，嚴禁意外自我注射。絕對不可用於一般麻醉。

作用機制

The combination works synergistically to ensure rapid and peaceful euthanasia:

  • Secobarbital → Rapidly and profoundly depresses the Central Nervous System (CNS), including the respiratory centers, leading to rapid loss of consciousness and cessation of respiration.
  • Cinchocaine → Exerts marked cardiotoxic effects at high doses. It depresses cardiac conduction → resulting in early cardiac arrest.

​Clinical Pearl:​ Because cardiac arrest is not dependent on the development of profound hypoxia, euthanasia with this combination is generally not accompanied by the agonal gasping that may occur with other agents.

安全性與警告

禁忌症

  • Must NOT be used for anesthesia (non-sterile and cardiotoxic)

不良反應

  • Pain on injection (if administered perivascularly)
  • Excitement (if administered perivascularly or too slowly)

注意事項

Patient Precautions

  • ​Injection Speed:​ Speed of injection is critical. An injection rate that is too slow may induce normal collapse but prolong the period until death. Administer over 10-15 seconds to minimize premature cardiac arrest before unconsciousness.
  • ​Route:​ Strictly intravenous. Perivascular administration may delay the onset of effect, cause pain, and result in excitement. Placement of an IV catheter is strongly recommended.
  • Always have an alternative method of euthanasia available.

Human Safety Warnings

​EXTREME DANGER TO HUMANS:​ Rapidly and highly toxic.

  • Use an IV catheter instead of a needle whenever possible to prevent accidental needle-stick injuries.
  • Only administer in the presence of an assistant.
  • Wear suitable protective gloves. Cinchocaine can cause hypersensitivity and severe contact dermatitis following skin contact.
  • Wash off splashes from skin and eyes immediately.
  • ​In the event of accidental self-administration:​ Do not leave the person unattended. Seek URGENT medical assistance, advise medical services of barbiturate and local anesthetic poisoning, and show the label. Maintain airways and provide symptomatic/supportive treatment.

監測

  • Confirmation of cardiac arrest (auscultation)
  • Confirmation of respiratory arrest
  • Absence of corneal reflex
  • Loss of pupillary light reflex

藥物動力學

吸收

Rapid onset following intravenous administration.

分佈

Rapidly distributes to the CNS.

過量

Not applicable. This medication is intended to induce death.

可用產品

劑型

  • Injectable: 400 mg/ml secobarbital with 25 mg/ml cinchocaine solution

獸醫用

  • Somulose Injectable Solution (400 mg/ml secobarbital, 25 mg/ml cinchocaine)

各地核准狀態

European Union✓ 已核准處方藥 · Schedule 2EMA
🐕 Dogs🐈 Cats

Controlled Drug

United Kingdom✓ 已核准處方藥 · Schedule 2VMD
🐕 Dogs🐈 Cats

POM-V CD SCHEDULE 2

暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Store in a locked receptacle in accordance with Controlled Drug Schedule 2 regulations.

飼主須知

此藥物僅供獸醫專業人員用於寵物的人道安樂死。它能確保寵物迅速、無痛且安詳地離世，減少其他方法可能帶來的喘息或不適。

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