磺胺嘧啶銀
磺胺嘧啶銀是一種局部抗菌劑，廣泛應用於獸醫學，用於治療和預防二度及三度燒傷以及其他淺表皮膚感染和創傷的感染。 **臨床提示：** 它對包括綠膿桿菌在內的廣泛細菌及部分酵母菌具有高度療效。由於其舒緩的乳膏基質和廣譜療效，在燒傷護理中特別受重視。
作用機制: Slowly releases **silver ions** in concentrations that are toxic to bacteria and yeasts. The **sulfadiazine** component also provides local anti-infective qualities by inhibiting bacterial folic acid synthesis. → Silver ions bind to bacterial DNA and cell membranes → disruption of cellular metabolism and structural integrity → cell death. → Sulfadiazine competitively inhibits **dihydropteroate synthase** → prevents bacterial folic acid synthesis.
各物種劑量
- Burns and superficial wound infections · Apply a thin layer (approx 1.5 mm thick) to the affected area · topical · sid to bid · Until healing is satisfactory · Clean and debride wound before application. Apply using sterile technique.
- Burns and superficial wound infections · Apply a thin layer (approx 1.5 mm thick) to the affected area · topical · sid to bid · Until healing is satisfactory · Clean and debride wound before application. Apply using sterile technique.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
給藥途徑
禁忌症
- Hypersensitivity to sulfonamides
- Use in pregnant or premature animals (theoretical risk of kernicterus)
不良反應
- Local irritation
- Erythema
- Skin discoloration (argyria) with prolonged use
- Delayed wound healing (in some cases)
藥物相互作用
- Topical proteolytic enzymes (e.g., collagenase) · Silver may inactivate the enzymes, reducing their debriding efficacy. · moderate
- Cimetidine · May increase the risk of leukopenia if significant systemic absorption occurs. · minor
監測
- Wound healing progress
- Signs of local irritation or hypersensitivity
- Complete blood count (CBC) if applied to very large areas for prolonged periods (due to theoretical risk of leukopenia)
過量
Overdose is highly unlikely with topical application. Ingestion of large amounts (e.g., if a pet licks a large treated area) may cause mild gastrointestinal upset or, rarely, systemic sulfonamide toxicity (crystalluria). Treatment is symptomatic and supportive.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。