碘化鈉 / 碘化鉀
Sodium Iodide / Potassium Iodide
Sodium Iodide, Potassium Iodide
別名: SSKI · Iodoject · Pima · Thyrosafe · Iosat · Potassium Iodide · Sodium Iodide · Ethylenediamine dihydroiodide · EDDI
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Sporotrichosis | 40 mg/kg PO q8h | PO | q8h | at least 60 days | 🌎 NA |
| Sporotrichosis | 40 mg/kg PO q12h | PO | q12h | — | 🌎 NA |
- Sporotrichosis: Using SSKI
- Sporotrichosis: Using SSKI; give with food. Itraconazole is less likely to have adverse effects.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Sporotrichosis | 20 mg/kg PO q12-24h | PO | q12-24h | at least 60 days | 🌎 NA |
| Sporotrichosis | 20 mg/kg PO q12-24h | PO | q12-24h | — | 🌎 NA |
- Sporotrichosis: Using SSKI; give with food. Itraconazole is less likely to cause adverse effects.
馬
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Sporotrichosis | 20-40 mg/kg PO daily | PO | q24h | several weeks | 🌎 NA |
| Sporotrichosis | Loading dose of sodium iodide at 20-40 mg/kg IV for 2-5 days, then 20-40 mg/kg PO once daily | IV, PO | q24h | at least 3 weeks after all clinical lesions disappear | 🌎 NA |
| Conidiobolomycosis | 20% sodium iodide at 44 mg/kg IV for 7 days, then ethylenediamine dihydroiodide at 1.3 mg/kg PO q12h for 4 months, then q24h for 1 year, then once per week | IV, PO | Variable | Over 1 year | 🌎 NA |
- Sporotrichosis: Sodium iodide
- Sporotrichosis: May administer via oral syringe or mixed in sweet feed. Topical hot packs of 20% sodium iodide may be used on open wounds.
- Conidiobolomycosis: Excessive lacrimation occasionally noted, but resolved if the drug was held for one day.
牛
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Actinobacillosis (woody tongue) | 70 mg/kg IV given as a 10% or 20% solution | IV | repeat at least one more time at a 7-10 day interval | — | 🌎 NA |
- Actinobacillosis (woody tongue): Refractory cases may require more frequent (2-3 day intervals) treatment. Severe cases may require adjunctive antibiotics.
羊
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Actinobacillosis | 70 mg/kg IV given as a 10% or 20% solution | IV | repeat at least one more time at a 7-10 day interval | — | 🌎 NA |
- Actinobacillosis: Refractory cases may require more frequent (2-3 day intervals) treatment.
山羊
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Actinobacillosis | 70 mg/kg IV given as a 10% or 20% solution | IV | repeat at least one more time at a 7-10 day interval | — | 🌎 NA |
- Actinobacillosis: Refractory cases may require more frequent (2-3 day intervals) treatment.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
概覽
碘化物主要用於獸醫學中治療特定的肉芽腫性感染。主要適應症包括反芻動物的放線桿菌病（木舌症）和放線菌病，以及馬、狗和貓的孢子絲菌病。偶爾也用作祛痰劑或碘缺乏症的補充劑。貓對碘化物毒性高度敏感，因此在貓身上使用存在爭議。
作用機制
The exact mechanism of action for treating actinobacillosis and sporotrichosis is unknown.
- Iodides possess little to no direct in vitro antimicrobial or antifungal activity.
- They are believed to act by modifying the granulomatous inflammatory process.
- Proposed mechanism: Iodides may enhance phagocytosis by macrophages or alter the immune response within granulomas, facilitating the breakdown of granulomatous tissue and allowing the body's immune system to clear the infection.
安全性與警告
禁忌症
- Known iodide hypersensitivity
- Lactating animals (excreted in milk)
- Hyperthyroidism
- Renal failure
- Severe dehydration
- Pregnancy (may cause abortion in cattle)
不良反應
- Excessive tearing (epiphora)
- Vomiting and nausea
- Anorexia / inappetence
- Nasal discharge
- Muscle twitching
- Cardiomyopathy
- Scaly haircoats and dandruff
- Hyperthermia
- Decreased milk production
- Decreased weight gain
- Coughing
- Diarrhea
- Goiter (especially in foals from supplemented mares)
- Cardiovascular failure (in severe toxicity)
注意事項
Do NOT inject intramuscularly (IM).
When administering parenterally to horses, give slowly intravenously and with extreme caution, as severe generalized reactions have been reported.
Cats are highly prone to developing iodism (iodide toxicity). Weigh risks versus benefits carefully, especially in pregnant animals, as anecdotal reports suggest it can cause abortion in cattle (FDA Category D in humans).
藥物相互作用
Iodides may decrease the efficacy of antithyroid medications.
Iodides may enhance the efficacy of thyroid medications.
監測
- Clinical efficacy (resolution of granulomatous lesions)
- Signs of iodism (excessive tearing, nasal discharge, scaly haircoats/dandruff, hyperthermia, coughing, diarrhea)
- Thyroid function (if used long-term)
藥物動力學
吸收
Rapidly and nearly completely absorbed from the gastrointestinal tract following oral administration.
分佈
Widely distributed throughout extracellular fluids. Actively concentrated in the thyroid gland, salivary glands, gastric mucosa, and choroid plexus.
代謝
Iodide is not metabolized but is incorporated into thyroid hormones (T3 and T4) in the thyroid gland.
排除
Primarily excreted by the kidneys into the urine. Also excreted in milk, saliva, and tears. Therapeutic efficacy of IV sodium iodide for actinobacillosis is rapid, with beneficial effects usually seen within 48 hours.
過量
Excessive iodine accumulation leads to a toxic syndrome known as iodism.
- Clinical Signs: Excessive tearing (epiphora), vomiting, anorexia, nasal discharge, muscle twitching, cardiomyopathy, scaly haircoats/dandruff, hyperthermia, decreased milk production and weight gain, coughing, inappetence, and diarrhea.
- Species Sensitivity: Cats are particularly prone to developing iodism. Young animals may be more susceptible than adults. Foals have developed goiter when mares were excessively supplemented.
- Severe Toxicity: Can progress to depression, hypothermia, and cardiovascular failure.
可用產品
劑型
- Injection: 20% (200 mg/mL)
- Oral solution: 1 g/mL (SSKI)
- Oral syrup: 62.5 mg/mL
- Oral tablets: 65 mg, 130 mg
- Oral powder/granules (Ethylenediamine dihydroiodide)
獸醫用
- Sodium Iodide Injection: 20 grams/100 mL (20%; 200 mg/mL) in 250 mL vials
- Oral iodide powders/granules (Active ingredient: ethylenediamine dihydroiodide)
人用標示
- Potassium Iodide Solution (SSKI): 1 gram/mL
- Potassium Iodide Oral Syrup (Pima): 62.5 mg/mL
- Potassium Iodide Oral Tablets: 65 mg, 130 mg (Thyrosafe, Iosat)
各地核准狀態
暫無法規資料: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store veterinary injectable products at room temperature (15-30°C). Store Supersaturated Potassium Iodide (SSKI) solution below 40°C (preferably 15-30°C) in a tight, light-resistant container; protect from freezing. Crystallization can occur at low temperatures; re-warming and shaking will usually redissolve crystals. If the solution turns brownish-yellow (oxidation), discard it. Physically incompatible with vitamins B and C injection.
飼主須知
由於此藥物味道極差，給貓狗口服時，請與食物或高脂液體（如全脂牛奶、冰淇淋）混合餵食，以提高適口性並減少噁心嘔吐。密切觀察寵物是否出現碘中毒跡象（如流淚過多、流鼻涕、咳嗽、嚴重皮屑、嘔吐或食慾不振），若有異常請立即聯繫獸醫。哺乳期動物不宜使用，因藥物會分泌至乳汁中。
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