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破傷風抗毒素

Tetanus antitoxin

Tetanus antitoxin (equine origin)

抗毒素 / 免疫血清IMIVSC

別名: Tetanus antitoxin Behring · TAT · Tetanus antiserum

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

各物種劑量

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概覽

破傷風抗毒素是一種抗血清，用於預防有破傷風風險的動物，以及治療早期臨床破傷風。它能中和游離的破傷風毒素，但對已結合神經受體的毒素無效。犬貓感染破傷風的風險極低，因此不建議常規預防。

作用機制

Antibodies in the antiserum bind directly to tetanus toxin (tetanospasmin) in the systemic circulation. → Neutralizes free toxin before it can enter the nervous system. → Cannot displace or neutralize toxin that has already bound to neural receptors.

安全性與警告

禁忌症

  • Cats (due to inability to metabolize phenol preservative)

不良反應

  • Anaphylactoid reactions
  • Hypersensitivity reactions (especially with repeated doses)

注意事項

​Fatal Toxicity in Cats:​ Avoid use in cats due to their inability to metabolize the phenol preservative found in the formulation. ​Anaphylaxis Risk:​ All antisera can produce anaphylactoid reactions, especially if the patient has previously received horse protein products. Repeated doses increase hypersensitivity risk. Have adrenaline or antihistamines readily available during administration.

監測

  • Signs of anaphylaxis (respiratory distress, hypotension, collapse) immediately post-administration
  • Progression or resolution of tetanus clinical signs

藥物動力學

吸收

Rapidly absorbed following IM or SC administration; immediate availability via IV route.

分佈

Distributed primarily within the extracellular fluid space.

代謝

Degraded by normal protein metabolism pathways.

排除

Cleared by the reticuloendothelial system.

過量

No specific information available. Repeated or excessive doses increase the risk of hypersensitivity and anaphylactoid reactions.

可用產品

劑型

  • Injectable: 1000 IU/ml solution

獸醫用

  • Tetanus antitoxin Behring 1000 IU/ml solution

各地核准狀態

United States✓ 已核准處方藥FDA/CVM
🐴 Horses🐄 Cattle🐑 Sheep🐷 Swine

Primarily approved for large animals.

European Union✓ 已核准處方藥EMA
🐴 Horses🐄 Cattle🐑 Sheep🐕 Dogs

停藥期: cattle meat 0 days

POM-V classification in the UK.

United Kingdom✓ 已核准處方藥VMD
🐴 Horses🐄 Cattle🐑 Sheep🐕 Dogs

POM-V

暫無法規資料: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Store in a refrigerator (2°C - 8°C). Do not freeze. Protect from light.

飼主須知

破傷風抗毒素用於中和傷口中破傷風細菌產生的毒素。在毒素結合神經之前及早給藥效果最佳。犬貓極少感染破傷風，因此不需要常規預防。給藥後請​密切觀察是否有過敏反應​，因為本產品含有馬蛋白成分。由於含有特定防腐劑，通常不適用於貓。

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