曲伏前列素
眼科前列腺素類似物
**曲伏前列素**是一種局部眼科前列腺素F2α類似物，主要用於獸醫學中治療**原發性犬青光眼**。它能快速有效降低眼內壓（IOP），常被用於急性原發性青光眼的緊急處理。其活性與拉坦前列素（latanoprost）相當，經常與其他局部抗青光眼藥物（如碳酸酐酶抑制劑）合併使用。 > **臨床警告：** 禁忌用於葡萄膜炎和晶狀體前脫位，但可能對晶狀體半脫位和後脫位有幫助。避免用於懷孕動物。
作用機制: Acts as an agonist for **prostaglandin F receptors** → increases **uveoscleral outflow** of aqueous humor → significantly reduces **intraocular pressure (IOP)**.
各物種劑量
Dogs
- Primary glaucoma / Lens subluxation / Posterior luxation · 1 drop per eye · topical · once daily (evening), or q8-12h · Often used in conjunction with other topical antiglaucoma drugs such as carbonic anhydrase inhibitors.
劑量為持牌獸醫專業人員的臨床參考。請務必對照最新藥品說明書及個別病患確認。
給藥途徑
Topical
禁忌症
- Uveitis
- Anterior lens luxation
- Pregnancy
不良反應
- Miosis (profound in dogs)
- Conjunctival hyperaemia
- Mild ocular irritation
- Increased iridal pigmentation (noted in humans, but not typically in dogs)
藥物相互作用
- Thiomersal-containing preparations · Incompatible; do not use in conjunction · major
監測
- Intraocular pressure (IOP)
- Signs of ocular irritation or inflammation
- Pupil size (miosis)
過量
No specific veterinary information provided. Overdosage is likely to cause profound miosis, conjunctival hyperaemia, and ocular irritation. Flush the eye with sterile saline if significant accidental overexposure occurs.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。