布林佐胺
Brinzolamide
別名: Azopt · Azarga
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Glaucoma | 1 drop/eye | topical | q8-12h | — | 🌍 EU |
- Glaucoma: Can be used alone or in combination with other topical drugs.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Glaucoma | 1 drop/eye | topical | q8-12h | — | 🌍 EU |
- Glaucoma: Ineffective in normal cats but may reduce IOP in glaucomatous cats.
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
概覽
布林佐胺是一種局部碳酸酐酶抑制劑，主要用於單獨或與其他局部藥物合併控制犬貓的青光眼。由於其生理pH值為7.5，通常比多佐胺 (dorzolamide) 具有更好的耐受性。
臨床提示： 雖然布林佐胺對降低血壓正常貓的眼內壓無效，但可成功降低青光眼貓的眼內壓 (IOP)。相比之下，多佐胺對正常和患有青光眼的犬貓皆有效。
作用機轉
Brinzolamide reduces intraocular pressure (IOP) by inhibiting the enzyme carbonic anhydrase within the ciliary body epithelium.
Inhibition of carbonic anhydrase → decreased formation of bicarbonate ions → reduced fluid transport → decreased rate of aqueous humour production.
安全性與警告
禁忌症
- Severe hepatic impairment
- Severe renal impairment
- Uveitis (specifically for the timolol combination, as timolol causes miosis)
- Anterior lens luxation (timolol combination)
- Pupil block (timolol combination)
不良反應
- Local ocular irritation
- Keratitis
- Blepharitis
- Hypokalaemia (cats, rare systemic effect)
- Metabolic acidosis (dogs, rare systemic effect)
- Bradycardia and hypotension (if using the timolol combination product)
注意事項
Normal ophthalmic handling precautions should be observed.
Warning: Systemic absorption can occur. Rarely, topical carbonic anhydrase inhibitors have been reported to cause hypokalaemia in cats and metabolic acidosis in dogs.
Combination Product Warning: Products containing timolol (a beta-blocker) can cause systemic bradycardia and hypotension, and induce miosis, making them inappropriate for patients with uveitis or anterior lens luxation.
監測
- Intraocular pressure (IOP)
- Signs of local ocular irritation (keratitis, blepharitis)
- Serum potassium and acid-base status (if prolonged use or systemic signs occur)
- Heart rate and blood pressure (if using timolol combination)
藥物動力學
吸收
Administered topically to the eye, but systemic absorption can occur, potentially leading to systemic side effects (e.g., metabolic acidosis, hypokalaemia).
過量
Excessive topical application may increase the risk of systemic absorption, potentially leading to metabolic acidosis or hypokalaemia (especially in cats). If the timolol combination is used, overdose may lead to significant bradycardia and hypotension. Treatment is supportive and symptomatic.
可用產品
劑型
- Ophthalmic drops: 10 mg/ml (1%)
- Ophthalmic drops: 1% brinzolamide + 0.5% timolol
人用標示
- Azopt 10 mg/ml (1%) ophthalmic drops in 5 ml bottle
- Azarga 1% brinzolamide + 0.5% timolol ophthalmic drops in 5 ml bottle
各地核准狀態
Human registered products used off-label in veterinary medicine under the cascade.
Human registered products (POM) used off-label in veterinary medicine under the cascade.
暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store at room temperature. Keep the bottle tightly closed when not in use.
飼主須知
請按照獸醫指示的確切滴數給藥。
- 給藥前後請洗手。
- 請勿讓滴管尖端接觸眼睛或任何其他表面，以防污染。
- 如果您需要使用一種以上的眼藥水，請在兩次給藥之間至少等待 5-10 分鐘。
- 觀察寵物是否有眼睛發紅、瞇眼或揉眼睛的跡象，若出現這些情況或寵物顯得無精打采，請聯繫您的獸醫。
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