布林佐胺
布林佐胺是一種局部**碳酸酐酶抑制劑**，主要用於單獨或與其他局部藥物合併控制犬貓的**青光眼**。由於其生理pH值為7.5，通常比多佐胺 (dorzolamide) 具有更好的耐受性。 > **臨床提示：** 雖然布林佐胺對降低血壓正常貓的眼內壓無效，但可成功降低青光眼貓的眼內壓 (IOP)。相比之下，多佐胺對正常和患有青光眼的犬貓皆有效。
作用機制: Brinzolamide reduces intraocular pressure (IOP) by inhibiting the enzyme **carbonic anhydrase** within the ciliary body epithelium. Inhibition of carbonic anhydrase → decreased formation of bicarbonate ions → reduced fluid transport → decreased rate of **aqueous humour production**.
各物種劑量
- Glaucoma · 1 drop/eye · topical · q8-12h · Can be used alone or in combination with other topical drugs.
- Glaucoma · 1 drop/eye · topical · q8-12h · Ineffective in normal cats but may reduce IOP in glaucomatous cats.
劑量為合格獸醫專業人員的臨床參考。請務必對照最新藥品仿單及個別病患確認。
給藥途徑
禁忌症
- Severe hepatic impairment
- Severe renal impairment
- Uveitis (specifically for the timolol combination, as timolol causes miosis)
- Anterior lens luxation (timolol combination)
- Pupil block (timolol combination)
不良反應
- Local ocular irritation
- Keratitis
- Blepharitis
- Hypokalaemia (cats, rare systemic effect)
- Metabolic acidosis (dogs, rare systemic effect)
- Bradycardia and hypotension (if using the timolol combination product)
監測
- Intraocular pressure (IOP)
- Signs of local ocular irritation (keratitis, blepharitis)
- Serum potassium and acid-base status (if prolonged use or systemic signs occur)
- Heart rate and blood pressure (if using timolol combination)
過量
Excessive topical application may increase the risk of systemic absorption, potentially leading to **metabolic acidosis** or **hypokalaemia** (especially in cats). If the timolol combination is used, overdose may lead to significant **bradycardia** and **hypotension**. Treatment is supportive and symptomatic.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。