色甘酸鈉
肥大細胞穩定劑
色甘酸鈉是一種**肥大細胞穩定劑**,主要用於控制**過敏性結膜炎**和**過敏性鼻炎**。其作用局限於給藥部位,因此非常適合在眼部和呼吸道局部使用。 > **臨床提示:** 在接觸已知過敏原之前作為預防性使用效果最佳,因為它能防止脫顆粒,而不是逆轉已釋放的組織胺的作用。
作用機制: Sodium cromoglicate works by **stabilizing mast cell membranes**. It inhibits the release of inflammatory mediators (such as **histamine** and **leukotrienes**) from sensitized mast cells by preventing calcium influx across the cell membrane. Allergen exposure → Mast cell activation blocked → **Prevention of degranulation** → Decreased allergic inflammation.
各物種劑量
Dogs
- Allergic reactions (conjunctivitis/rhinitis) · 1-2 drops in eye or nose · Topical · q6h
Cats
- Allergic reactions (conjunctivitis/rhinitis) · 1-2 drops in eye or nose · Topical · q6h
劑量為合格獸醫專業人員的臨床參考。請務必對照最新藥品仿單及個別病患確認。
給藥途徑
Topical (Ophthalmic)Topical (Nasal)PO
禁忌症
- Known hypersensitivity to cromoglicate
不良反應
- Local irritation
- Transient stinging or burning upon application
監測
- Resolution of allergic clinical signs (e.g., reduced ocular discharge, conjunctival hyperemia, or sneezing)
過量
Due to poor systemic absorption, systemic toxicity from topical or oral overdose is highly unlikely. Overdose may result in increased local irritation.
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