VetSheet

去鐵胺

Deferoxamine

解毒劑 / 螯合劑IMIV狗貓

別名: Desferal · Desferrioxamine · Deferoxamine mesylate

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

40 mg/kg i.m. q4-8h or 15 mg/kg/h slow i.v. infusionIM/IV· q4-8h (IM) or continuous (IV)· Until iron levels normalize

這是依速率計算的持續輸注（CRI）劑量；須計算輸注速率，不能只依體重換算。

劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。

各物種劑量

🌎 NA — North America🌍 EU — Europe

狗

適應症劑量途徑頻次療程地區
Iron toxicity40 mg/kg i.m. q4-8h or 15 mg/kg/h slow i.v. infusionIM/IVq4-8h (IM) or continuous (IV)Until iron levels normalize🌍 EU
  • Iron toxicity: Slow IV infusion is preferred to avoid hypotension.

貓

適應症劑量途徑頻次療程地區
Iron toxicity40 mg/kg i.m. q4-8h or 15 mg/kg/h slow i.v. infusionIM/IVq4-8h (IM) or continuous (IV)Until iron levels normalize🌍 EU
  • Iron toxicity: Slow IV infusion is preferred to avoid hypotension.

劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。

正在看診？VetSheet 的 AI 會把藥物、劑量與療程直接寫入結構化的看診紀錄。了解 VetSheet 如何運作

概覽

去鐵胺是一種重金屬螯合劑，主要用作鐵中毒的解毒劑。快速靜脈注射可能引起嚴重的低血壓和過敏反應。

作用機轉

Deferoxamine chelates iron by binding to free iron (Fe3+) in the blood and tissues, forming a stable, water-soluble complex called ferrioxamine.

Free Iron + Deferoxamine → Ferrioxamine complex → Excreted in the urine.

安全性與警告

禁忌症

  • Severe renal disease

不良反應

  • Pain at IM injection site
  • Anaphylactic reactions (especially with rapid IV)
  • Hypotension (if administered rapidly IV)

注意事項

Normal precautions should be observed. Do not administer rapidly intravenously due to the high risk of hypotension and anaphylaxis. Use slow IV infusion instead.

監測

  • Serum iron levels
  • Total iron-binding capacity (TIBC)
  • Blood pressure (especially during IV infusion)
  • Renal function (BUN, Creatinine)
  • Urine color

藥物動力學

吸收

Well absorbed after IM administration.

分佈

Distributes widely but does not readily cross the blood-brain barrier.

代謝

Metabolized by plasma enzymes.

排除

The deferoxamine-iron complex (ferrioxamine) is excreted primarily in the urine.

過量

Overdosage or rapid IV administration can lead to acute hypotension, tachycardia, and shock. Treatment is supportive, including IV fluids and slowing/stopping the infusion.

可用產品

劑型

  • Injectable: 500 mg vial for reconstitution

人用標示

  • Desferal 500 mg powder for solution for injection/infusion

各地核准狀態

European Union✓ 已核准處方藥EMA
🐕 Dogs🐈 Cats

POM

United Kingdom✓ 已核准處方藥VMD
🐕 Dogs🐈 Cats

POM

暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Store un-reconstituted vials at room temperature. Reconstituted solutions should be used promptly or stored according to manufacturer guidelines.

飼主須知

此藥物用於治療嚴重的鐵中毒。治療期間寵物的尿液可能會變成紅橙色，這是正常現象（鐵被排出體外）。

VetSheet 藥物參考供合格獸醫專業人員作臨床決策輔助之用，不能取代專業判斷或廠商最新仿單。