去氧皮質酮
皮質類固醇 - 鹽皮質激素
長效型鹽皮質激素替代療法，用於治療患有原發性腎上腺皮質機能減退症（愛迪生氏病）的犬貓。開始治療前必須確診。若出現愛迪生氏危象，必須先進行靜脈輸液（生理食鹽水）補充水分。
作用機制: Acts as a **mineralocorticoid** replacement. It binds to mineralocorticoid receptors in the distal renal tubules → increases sodium reabsorption and promotes potassium excretion → restores electrolyte balance and maintains extracellular fluid volume and blood pressure.
各物種劑量
Cats
- Primary hypoadrenocorticism (Addison's disease) · Initial dose 2.2 mg/kg · SC · long-acting · Long-term replacement · Experience is limited but higher doses seem to be needed.
Dogs
- Primary hypoadrenocorticism (Addison's disease) · Initial dose 1.5-2.2 mg/kg (final dose can be between 1.0 and 2.7 mg/kg) · SC · long-acting (interval not specified in text) · Long-term replacement · Many authorities start at the lower dose of 1.5 mg/kg SC, particularly in larger dogs.
劑量為合格獸醫專業人員的臨床參考。請務必對照最新藥品仿單及個別病患確認。
給藥途徑
SC
禁忌症
- None strictly listed, but use with caution in congestive heart disease, severe renal disease, primary hepatic failure, or oedema
不良反應
- Pain on injection (rarely repeated in the same animal)
- Polyuria
- Polydipsia
- Hypokalaemia (with overdose)
- Vomiting
- Anorexia
- Muzzle swelling
- Anaphylaxis
藥物相互作用
- Spironolactone · Aldosterone antagonist; counteracts the effects of desoxycortone · major
- Furosemide · May excessively reduce potassium levels · moderate
- Thiazides · May excessively reduce potassium levels · moderate
監測
- Serum sodium and potassium levels
- Hydration status
- Renal function parameters (BUN, Creatinine)
- Clinical signs of Addison's relapse or overdosage (PU/PD)
過量
Overdoses may cause **polyuria** and **hypokalaemia**. Monitor electrolytes closely if overdose is suspected.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。