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依西泮泰

Epsiprantel

Pyrazino-benzazepine

抗寄生蟲藥 - 抗絛蟲藥PO狗貓

別名: Cestex · BRL-38705

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

5.5 mg/kg (2.5 mg/lb)PO· once· Single dose
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劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。

各物種劑量

🌎 NA — North America🌍 EU — Europe

狗

適應症劑量途徑頻次療程地區
Cestode infection (Dipylidium caninum, Taenia pisiformis)5.5 mg/kg (2.5 mg/lb)POonceSingle dose🌎 NA
  • Cestode infection (Dipylidium caninum, Taenia pisiformis): Round up to the next larger tablet size

貓

適應症劑量途徑頻次療程地區
Cestode infection (Dipylidium caninum, Taenia taeniaeformis)2.75 mg/kgPOonceSingle dose🌎 NA
  • Cestode infection (Dipylidium caninum, Taenia taeniaeformis): Cats up to 10 lb should receive one 12.5 mg tablet; cats 11-20 lb should receive one 25 mg tablet

劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。

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概覽

依西泮泰（Epsiprantel）是一種專門用於犬貓的口服​抗絛蟲藥物​。

  • ​適應症​：有效清除犬隻的犬瓜實絛蟲（Dipylidium caninum）與豆狀帶絛蟲（Taenia pisiformis），以及貓隻的犬瓜實絛蟲與貓帶絛蟲（Taenia taeniaeformis）。
  • ​臨床要點​：與吡喹酮（Praziquantel）不同，依西泮泰在胃腸道的吸收極差，這使其具有極高的安全性且幾乎沒有全身性副作用。

作用機轉

While the exact mechanism of action against cestodes is not fully elucidated, epsiprantel acts directly on the tapeworm:

  • Calcium Dysregulation → Induces severe tetany (muscle spasms) in the parasite.
  • Attachment Disruption → Causes the tapeworm to lose its grip on the host's intestinal mucosa.
  • Integument Alteration → Damages the worm's outer protective layer, rendering it highly vulnerable to digestion by the host animal's gastrointestinal enzymes.

安全性與警告

禁忌症

  • Puppies less than 7 weeks of age
  • Kittens less than 7 weeks of age

不良反應

  • Vomiting (rare)
  • Diarrhea (rare)

注意事項

Age Restriction: The manufacturer states not to use in puppies or kittens less than 7 weeks of age.

Safety for use in pregnant or breeding animals has not been definitively determined, though teratogenic effects are highly unlikely due to the drug's extremely poor systemic absorption.

藥物交互作用

Prokinetic agents

Theoretically may reduce the drug's efficacy by decreasing gastrointestinal transit time

Fast-acting laxatives

Theoretically may reduce the drug's efficacy

監測

  • Clinical efficacy (resolution of tapeworm infection)

藥物動力學

吸收

Absorbed very poorly after oral administration.

分佈

Remains primarily within the gastrointestinal tract.

代謝

No metabolites have thus far been detected.

排除

The bulk of the drug is eliminated unchanged in the feces. Less than 0.1% of the drug is recovered in the urine after dosing.

過量

Acute toxicity resulting from an inadvertent overdose is highly unlikely due to poor systemic absorption.

  • Cats: Doses as high as 36X the recommended dose resulted in vomiting in some of the kittens tested.
  • Dogs: Single doses of 36X those recommended in dogs caused no adverse effects.

可用產品

劑型

  • Oral tablets

獸醫用

  • Epsiprantel Oral Tablets (Film-coated): 12.5 mg, 25 mg, 50 mg & 100 mg; Cestex® (Pfizer)

各地核准狀態

暫無法規資料: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Tablets should be stored at room temperature.

飼主須知

  • ​無需禁食​：給藥前不需要（也不建議）讓寵物禁食。可以隨餐或空腹給藥。
  • ​糞便中可能看不到蟲體​：因為藥物會使絛蟲在體內被部分或完全消化，治療後您通常​不會在糞便中看到絛蟲碎片​。
  • ​預防再次感染​：單次劑量通常即可見效。但由於最常見的犬瓜實絛蟲是透過吞食受感染的跳蚤傳播，因此​嚴格的跳蚤控制​對於防止寵物再次感染至關重要。

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