氟雷拉納
Fluralaner
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide
別名: Bravecto Plus · Fluralanerum
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
經審核的 v13 劑量證據
結構化劑量計算證據Otodectes cynotis (extra-label)
須由已驗證獸醫確認
- once
NA
必須一併考量的臨床脈絡 (1)
- Do not store fluralaner chewable tablets above 30°C (86°F) or topical solutions above 25°C (77°F). Store in the original packaging to protect from moisture. The topical solution is highly flammable. Keep away from heat, sparks, open flame, or other sources of ignition.
Sarcoptes scabiei var canis infestation (extra-label)
須由已驗證獸醫確認
- once
NA
必須一併考量的臨床脈絡 (1)
- Do not store fluralaner chewable tablets above 30°C (86°F) or topical solutions above 25°C (77°F). Store in the original packaging to protect from moisture. The topical solution is highly flammable. Keep away from heat, sparks, open flame, or other sources of ignition.
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
概覽
氟雷拉納是一種全身性異惡唑啉類體外寄生蟲殺滅劑，主要用於治療和預防犬貓的跳蚤和壁蝨感染。它具有長效作用（每劑通常可維持長達12週）。
臨床提示： 犬用口服咀嚼錠必須與食物一起投予，以最大化胃腸道吸收。對於有癲癇或神經系統疾病病史的動物，請謹慎使用。
作用機轉
Fluralaner acts as an ectoparasiticide by antagonizing ligand-gated chloride channels.
It specifically targets channels gated by the neurotransmitter gamma-aminobutyric acid (GABA) and glutamate (GluCl) → blocks pre- and post-synaptic transfer of chloride ions across cell membranes → results in uncontrolled central nervous system activity and death of insects and acarines.
安全性與警告
禁忌症
- Known hypersensitivity to fluralaner or any excipients
- Use with caution in dogs or cats with pre-existing epilepsy or seizure disorders
- Puppies less than 8 weeks of age or weighing less than 2 kg
- Kittens less than 11 weeks of age or weighing less than 1.2 kg
不良反應
- Vomiting
- Diarrhea
- Lethargy
- Decreased appetite
- Application site reactions (erythema, pruritus, alopecia for topical forms)
- Rare neurological signs (muscle tremors, ataxia, seizures)
- Neurologic signs (tremors, ataxia, seizures - rare)
- Application site reactions (erythema, pruritus - topical forms)
注意事項
Neurologic Warning: Isoxazolines have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures, even in animals without a prior history.
Ensure accurate dosing based on body weight. Do not break or divide chewable tablets.
藥物交互作用
Fluralaner is highly bound to plasma proteins and might theoretically compete with other highly bound drugs, though clinical significance is generally low.
Fluralaner is highly protein-bound and may theoretically compete with other highly bound drugs, though clinical significance is generally considered low.
監測
- Efficacy of parasite control
- Signs of gastrointestinal upset
- Neurological status (especially in animals with a history of seizures)
- Adverse neurologic signs (tremors, ataxia, seizures)
藥物動力學
半衰期
吸收
Readily absorbed following oral administration in dogs when given with food. Topical formulations are absorbed systemically through the skin.
分佈
Highly bound to plasma proteins. Distributes widely to tissues, particularly fat, which acts as a depot.
代謝
Undergoes minimal hepatic metabolism.
排除
Eliminated primarily unchanged in the feces via biliary excretion, with a very minor portion excreted in urine.
過量
Fluralaner is generally well tolerated. In safety studies, oral administration of up to 5 times the maximum recommended dose in dogs produced no severe adverse effects. Overdoses may increase the risk of gastrointestinal upset or transient neurological signs. Treatment is symptomatic and supportive.
可用產品
劑型
- Oral chewable tablets (dogs)
- Topical spot-on solution (dogs and cats)
- Topical spot-on solution with moxidectin (cats)
- Topical spot-on solution combined with moxidectin (cats)
獸醫用
- Bravecto chewable tablets for dogs (112.5 mg, 250 mg, 500 mg, 1000 mg, 1400 mg)
- Bravecto spot-on solution for dogs and cats (280 mg/ml)
- Bravecto Plus spot-on solution for cats (280 mg/ml fluralaner + 14 mg/ml moxidectin)
- Bravecto spot-on for dogs and cats (280 mg/ml)
- Bravecto Plus spot-on for cats (280 mg/ml fluralaner + 14 mg/ml moxidectin)
各地核准狀態
FDA approved for flea and tick control.
POM-V
POM-V
暫無法規資料: 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store at room temperature (below 30°C). Keep in original packaging to protect from moisture and light.
飼主須知
請在餵食時或飯後立即將咀嚼錠餵給您的愛犬，以確保藥物被妥善吸收。本藥物可提供長達12週的跳蚤和壁蝨防護。投藥後請觀察寵物是否有輕微的腸胃不適（嘔吐或腹瀉）。如果您發現寵物出現任何肌肉顫抖、動作不協調或癲癇發作的情況，請立即聯繫您的獸醫師。
VetSheet 藥物參考供合格獸醫專業人員作臨床決策輔助之用，不能取代專業判斷或廠商最新仿單。