醋丙氫化可的松
Hydrocortisone aceponate
別名: Cortavance · Easotic · HCA · Hydrocortisone 21-acetate 17-propionate
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Pruritic inflammatory skin disease | 2 pumps of spray per 10 cm x 10 cm square of skin (delivers 1.52 μg/cm2) | topical | q24h | 7 days | 🌍 EU |
| Otitis externa | 1 pump (1 ml) per ear | topical | q24h | 5 days | 🌍 EU |
- Pruritic inflammatory skin disease: Cortavance spray
- Otitis externa: Easotic (combination product)
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| General | Dose not established | topical | unknown | unknown | 🌍 EU |
- General: Safety and efficacy not fully established in cats.
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
概覽
醋丙氫化可的松 (Hydrocortisone aceponate) 是一種強效的局部皮質類固醇，在獸醫學中主要用於治療發炎性和搔癢性皮膚病，以及急性或復發性外耳炎。
臨床提示： 作為一種雙酯前驅藥物，它在皮膚局部提供高強度的抗發炎功效，同時顯著減少全身性吸收及與糖皮質激素相關的典型全身性副作用（如腎上腺抑制或肝酶升高）。
作用機轉
Hydrocortisone aceponate is a highly lipophilic pro-drug. Upon application, it penetrates the stratum corneum and is biotransformed by local esterases in the epidermis → hydrocortisone 17-propionate (the active form). It binds to local glucocorticoid receptors to inhibit inflammatory pathways, reducing erythema, pruritus, and swelling, while its rapid local metabolism minimizes systemic distribution.
安全性與警告
禁忌症
- Ulcerated skin
- Perforated tympanic membrane (ear drum)
- Cutaneous ulcers
- Known hypersensitivity to corticosteroids
- Concurrent systemic viral or fungal infections
- Use on large surface areas for prolonged periods without veterinary supervision
不良反應
- Epidermal atrophy (with protracted use)
- Aural erythema (otic preparation)
- Transient hearing loss in geriatric dogs (rare, otic preparation)
- Transient local erythema
- Skin thinning or atrophy (rare, usually only with prolonged use)
- Delayed wound healing
- Systemic glucocorticoid effects (extremely rare due to rapid metabolism)
注意事項
Do not use on ulcerated skin or if the ear drum is perforated.
- Growth Warning: Use with caution in dogs <7 months old, as glucocorticoids are known to slow growth.
- Surface Area Limits: The total body surface treated should not exceed a surface corresponding to a treatment of two flanks (from the spine to the mammary chains, including shoulders and thighs).
- Infections: Microbial infections should be treated appropriately prior to use.
- Monitoring: Patients should be monitored appropriately during long-term use to watch for epidermal atrophy or systemic absorption.
藥物交互作用
Increased risk of local skin atrophy and potential systemic absorption
監測
- Resolution of pruritus and inflammation
- Signs of epidermal atrophy (skin thinning) with prolonged use
- Liver enzyme activities (during long-term use)
- Cortisol response to ACTH stimulation (during long-term use)
- Resolution of pruritus and erythema
- Signs of local skin thinning or atrophy with prolonged use
藥物動力學
半衰期
吸收
Highly lipophilic; penetrates the epidermis well but systemic absorption is minimal, reducing systemic side effects.
分佈
Primarily localized to the epidermal and dermal layers of the skin at the site of application.
代謝
Biotransformed locally in the epidermis to its active form, hydrocortisone 17-propionate.
排除
Cleared locally with minimal systemic circulation.
過量
Massive over-application or protracted use can result in epidermal atrophy (thinning of the skin). While systemic effects (such as increases in liver enzyme activities or depression of cortisol response to ACTH stimulation) are minimized by the pro-drug formulation, they may theoretically occur with significant overdosage or ingestion.
可用產品
劑型
- Topical spray: 0.584 mg/ml
- Otic suspension: 1.11 mg/ml (combined with miconazole 15.1 mg/ml and gentamicin 1505 IU/ml)
- Topical spray (0.0584%)
- Otic suspension (in combination with miconazole and gentamicin)
獸醫用
- Cortavance 76 ml spray (0.584 mg/ml)
- Easotic suspension for ears (1.11 mg/ml hydrocortisone aceponate, 15.1 mg/ml miconazole, 1505 IU/ml gentamicin)
- Cortavance 0.0584% cutaneous spray, solution for dogs
- Easotic ear drops, suspension for dogs (combination with gentamicin and miconazole)
各地核准狀態
Approved for veterinary use in dogs.
POM-V classification.
暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Normal precautions should be observed. Store at room temperature and keep out of reach of children.
飼主須知
請完全按照獸醫師的指示使用此藥物。
- 請勿塗抹於開放性傷口或潰瘍的皮膚上。
- 如果使用耳滴劑，獸醫師必須在開始治療前確認耳膜完整無損。
- 避免噴灑在眼睛或嘴巴附近。
- 塗抹藥物後請洗手，或戴上手套操作。
- 如果您發現寵物耳朵發紅、皮膚看起來異常變薄，或者您的老年犬似乎有聽力困難，請立即聯繫您的獸醫師。
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