羥丙甲纖維素
眼科潤滑劑 / 人工淚液
羥丙甲纖維素是一種基於纖維素的水性淚液替代品，用於替代三層淚膜中的水性成分。它作為一種擬淚劑，可提供潤滑並緩解眼部乾燥。 **臨床提示：** 常用於動物的乾眼症（KCS）管理，通常與環孢素或他克莫司等淚液刺激劑合併使用。由於它是水性替代品，與較黏稠的眼藥膏或凝膠相比，需要更頻繁地使用。
作用機制: Hypromellose is a hydrophilic polymer that acts as a **lacrimomimetic**. It increases the viscosity of tears and prolongs corneal contact time. Cellulose-based polymer → binds to existing tears → stabilizes the aqueous layer of the trilaminar tear film → prevents rapid tear evaporation and provides mechanical lubrication to the cornea and conjunctiva.
各物種劑量
Dogs
- Keratoconjunctivitis sicca (dry eye) / Ocular lubrication · 1-2 drops per affected eye · Topical (Ophthalmic) · q4h to q12h (or as frequently as needed) · Ongoing · Frequency depends on the severity of dry eye. May be used as often as every 1-2 hours in severe cases.
SmallMammals
- Ocular lubrication (e.g., during anesthesia or for exophthalmos) · 1 drop per eye · Topical (Ophthalmic) · As needed · Ongoing · Useful to prevent corneal desiccation during anesthesia.
Cats
- Ocular lubrication · 1-2 drops per affected eye · Topical (Ophthalmic) · q4h to q12h (or as frequently as needed) · Ongoing · Frequency depends on the severity of dry eye.
劑量為合格獸醫專業人員的臨床參考。請務必對照最新藥品仿單及個別病患確認。
給藥途徑
Topical (Ophthalmic)
禁忌症
- Hypersensitivity to hypromellose or any component of the formulation (such as preservatives like benzalkonium chloride in multi-dose bottles)
不良反應
- Transient blurred vision immediately after application
- Mild ocular irritation or stinging (rare)
- Crusting on the eyelids from dried polymer
藥物相互作用
- Other topical ophthalmic medications · May wash out other eye drops if administered simultaneously. Hypromellose can also act as a barrier if applied before other drugs. · minor
監測
- Resolution of clinical signs of dry eye (e.g., redness, mucoid discharge, blepharospasm)
- Schirmer Tear Test (STT) if managing KCS
- Corneal staining (fluorescein) to monitor for corneal ulceration secondary to dry eye
過量
Overdosage is highly unlikely due to the topical route of administration and lack of systemic absorption. Excess drops will simply overflow from the eye.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。