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碳酸鑭

Lanthanum Carbonate

Lanthanum carbonate (octa-hydrate)

磷結合劑PO狗貓

別名: Fosrenol · Lantharenol · Renalzin · Bay-78-1887 · Lanthanum

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

100 mg/kg/dayPO· divided between meals· Chronic
— 🐕

劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。

各物種劑量

🌎 NA — North America🌍 EU — Europe

狗

適應症劑量途徑頻次療程地區
Chronic kidney disease (Hyperphosphataemia)100 mg/kg/dayPOdivided between mealsChronic🌍 EU
  • Chronic kidney disease (Hyperphosphataemia): Dose adjustments should be based on serum phosphate levels monitored at 4-6 week intervals.

貓

適應症劑量途徑頻次療程地區
Phosphate binder200 mg (total dose) PO (on/in food) 2-3 times daily.PO2-3 times daily—🌎 NA
Phosphate binder (using Renalzin)2 mLs (400 mg) applied in the cat's food, once or twice daily depending on the cat's feeding regimen.POonce or twice daily—🌎 NA
Chronic kidney disease (Hyperphosphataemia)400-800 mg/cat/dayPOdivided according to feeding schedule (give some with every meal)Chronic🌍 EU
  • Phosphate binder: Anecdotally appears safe and effective.
  • Chronic kidney disease (Hyperphosphataemia): Recommended starting dose is 400 mg per day. It is important to give some with every meal.

劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。

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概覽

碳酸鑭是一種口服磷結合劑，主要用於控制末期腎病 (ESRD) 患畜的高血磷症。

雖然限制飲食中的磷是控制慢性腎病 (CKD) 的基礎，但當單靠飲食無法控制或患畜拒絕食用處方飼料時，就需要使用磷結合劑。

​臨床要點：​ 與鈣基結合劑（可能引起高血鈣）或鋁基結合劑（長期使用有鋁中毒風險）不同，鑭不含鈣與鋁，是獸醫臨床上長期控制高血磷的理想選擇。

作用機轉

Lanthanum carbonate acts locally in the gastrointestinal tract.

  • It dissociates in the acidic environment of the upper GI tract (stomach) to release ​lanthanum ions (La³⁺)​.
  • These ions bind to dietary phosphate → forming highly insoluble lanthanum phosphate complexes.
  • These complexes cannot cross the intestinal mucosa and are subsequently eliminated in the feces, thereby reducing net intestinal absorption of phosphorus.

安全性與警告

禁忌症

  • Patients with non-intact GI tract (e.g., GI ulcers, colitis) - use with caution due to increased risk of systemic absorption
  • Acute renal crisis (patients should be stabilized first)

不良反應

  • Inappetence
  • None known according to the monograph
  • Gastrointestinal upset (nausea, vomiting, diarrhea, or constipation) may occur (Clinical Pearl)

注意事項

There are no listed absolute contraindications, but it should be used with caution in patients where the GI tract is not intact (e.g., GI ulcers, colitis) as there is an increased chance for oral absorption. Safe for use during pregnancy and nursing.

藥物交互作用

Allopurinol

Potential decreased absorption; separate dosing by 2 hours

Chloroquine

Potential decreased absorption; separate dosing by 2 hours

Corticosteroids

Potential decreased absorption; separate dosing by 2 hours

Digoxin

Potential decreased absorption; separate dosing by 2 hours

Ethambutol

Potential decreased absorption; separate dosing by 2 hours

Fluoroquinolones

Potential decreased absorption; separate dosing by 2 hours

H-2 Antagonists (ranitidine, famotidine)

Potential decreased absorption; separate dosing by 2 hours

Iron Salts

Potential decreased absorption; separate dosing by 2 hours

Isoniazid

Potential decreased absorption; separate dosing by 2 hours

Penicillamine

Potential decreased absorption; separate dosing by 2 hours

Phenothiazines

Potential decreased absorption; separate dosing by 2 hours

Tetracyclines

Potential decreased absorption; separate dosing by 2 hours

Thyroid Hormones

Potential decreased absorption; separate dosing by 2 hours

Other oral medicationsModerate

Lanthanum may bind to other drugs in the GI tract, reducing their absorption. Should be given at least 1 hour before or 3 hours after other medications.

監測

  • Serum phosphorous
  • Serum potassium
  • Serum bicarbonate
  • Serum chloride
  • Serum phosphate levels (at 4-6 week intervals to adjust dosage and achieve target concentrations)
  • Renal parameters (BUN, Creatinine, SDMA)
  • Serum calcium levels

藥物動力學

半衰期

貓Not applicable (acts locally in GI tract)狗Not applicable (acts locally in GI tract)

吸收

Following oral doses, lanthanum bioavailability is very low (less than 0.002%).

分佈

Systemically available lanthanum is very highly bound to plasma proteins (>99%). Tissue levels increase over time and can be several orders of magnitude higher than plasma levels. Highest levels found in GI tract, bone, and liver.

代謝

Not metabolized. It is an inorganic salt.

排除

Absorbed lanthanum is cleared primarily via biliary excretion into the feces. In dogs, mean recovery of an oral dose averages 94%.

過量

No specific information located, but acute overdose is likely tolerated with potential for GI effects. Only supportive treatment should be required. In cats, oral dosages up to 1 gram/kg were tolerated, but repeated vomiting occurred at 2 grams/kg.

可用產品

劑型

  • Chewable tablets
  • Pump gel/paste
  • 500 mg chewable tablet
  • 750 mg chewable tablet
  • 1 g chewable tablet

獸醫用

  • Renalzin (lanthanum carbonate, kaolin, vitamin E) pump gel/paste (200 mg/mL) - Available in some countries outside USA/Canada
  • Lantharenol (General sale / Feed additive - availability varies)

人用標示

  • Fosrenol Oral Chewable Tablet 500 mg, 750 mg, & 1,000 mg
  • Fosrenol 500 mg chewable tablets
  • Fosrenol 750 mg chewable tablets
  • Fosrenol 1 g chewable tablets

各地核准狀態

European Union✓ 已核准處方藥EMA
🐕 Dogs🐈 Cats

Fosrenol is POM; Lantharenol has been marketed as a general sale feed additive.

United Kingdom✓ 已核准處方藥VMD
🐕 Dogs🐈 Cats

Fosrenol is POM; Lantharenol has been marketed as a general sale feed additive.

暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

儲存與穩定性

Store tablets at room temperature (25°C, 77°F); excursions are permitted to 15°-30°C (59°-86°F). Protect from moisture.

飼主須知

  • ​給藥方式：​ 請勿讓動物整顆吞下藥錠。請將藥錠壓碎並與動物的食物充分混合。
  • ​給藥時間：​ 必須​隨餐​給予，以便藥物能與食物中的磷結合。
  • ​市售獸醫產品：​ 若使用特定的獸醫專用凝膠/膏劑，請遵循標籤上的確切給藥指示。
  • ​副作用：​ 觀察是否有嘔吐或食慾不振的情況，若發生請聯繫您的獸醫師。

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