洛替拉納
體外寄生蟲驅殺藥 (異噁唑啉類)
洛替拉納是一種屬於異噁唑啉類的全身性體外寄生蟲驅殺藥，用於治療和預防犬貓的跳蚤和壁蝨感染。 **臨床提示：** 異噁唑啉類藥物非常有效且起效迅速，但寄生蟲必須附著並開始吸血才能接觸到有效成分。
作用機制: Lotilaner acts as an antagonist at **gamma-aminobutyric acid (GABA)-gated chloride channels** and, to a lesser extent, **glutamate-gated chloride channels** (GluCls) in insects and acarines. Binding blocks the transfer of chloride ions across cell membranes → uncontrolled neuromuscular activity → paralysis → death of the parasite.
各物種劑量
Dogs
- Parasite control (fleas and ticks) · 1 tablet of appropriate size (56.25 mg, 112.5 mg, 225 mg, 450 mg, or 900 mg) based on body weight · PO · monthly · Ongoing · Administer with food or within 30 minutes of feeding.
Cats
- Parasite control (fleas and ticks) · 1 tablet of appropriate size (12 mg or 48 mg) based on body weight · PO · monthly · Ongoing · Administer with food or within 30 minutes of feeding.
劑量為合格獸醫專業人員的臨床參考。請務必對照最新藥品仿單及個別病患確認。
給藥途徑
PO
禁忌症
- Hypersensitivity to the active substance
- Puppies less than 8 weeks of age or weighing less than 1.3 kg (dog product)
- Kittens less than 8 weeks of age or weighing less than 0.5 kg (cat product)
不良反應
- Vomiting
- Diarrhea
- Lethargy
- Anorexia
- Neurological signs (tremors, ataxia, seizures) - rare
監測
- Clinical efficacy (absence of fleas and ticks)
- Adverse neurological signs (rare)
過量
Lotilaner is generally well tolerated even at multiple times the maximum recommended dose. Overdose may cause mild, transient gastrointestinal signs such as vomiting or diarrhea. Treatment is symptomatic and supportive.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。