聚乙二醇 / 巨球經
含有**聚乙二醇 (Macrogol)** 的腸道清潔液作為滲透性瀉藥。它們配有平衡的電解質以維持等滲透壓，防止在腸道準備過程中發生淨水分流失或增加。口服後能迅速排空腸道。 > **臨床提示：** 主要用於結腸鏡檢查、胃腸道X光檢查或手術前的腸道準備，偶爾也用於處理嚴重的頑固性便秘或糞便嵌塞。
作用機制: **Polyethylene glycol** acts as an **osmotic laxative**. It is a large, non-absorbable polymer that binds water → retains fluid within the colonic lumen → increases fecal volume and softens stool → stimulates colonic motility and peristalsis → rapidly empties the bowel. The addition of balanced electrolytes ensures isotonicity, preventing significant shifts of sodium, potassium, or water across the intestinal mucosa.
給藥途徑
禁忌症
- Gastrointestinal obstruction
- Bowel perforation
- Gastric retention
- Toxic megacolon
- Severe dehydration
不良反應
- Nausea
- Vomiting
- Abdominal cramping
- Bloating
- Fluid and electrolyte imbalances (rare if formulated with electrolytes)
藥物相互作用
- Oral medications · Decreased absorption due to rapid gastrointestinal transit time · moderate
監測
- Fecal output and consistency
- Hydration status
- Serum electrolytes (in prolonged or high-dose use)
過量
Overdosage may result in severe diarrhea, leading to significant fluid and electrolyte loss. Treatment is primarily supportive, focusing on intravenous fluid therapy to restore hydration and correct any electrolyte derangements.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。