酒石酸莫侖太爾
Morantel Tartrate
Morantel tartrate
別名: Rumatel · Goat Care-2X · CP-12009-18 · moranteli hydrogenotartras · UK-2964-18
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
牛
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Susceptible parasites | 9.68 mg/kg | PO | Single dose | — | 🌎 NA |
| Susceptible parasites | 0.44 grams of morantel tartrate per 100 lbs of body weight | PO | Single dose | — | 🌎 NA |
| Susceptible parasites | 8.8 mg/kg | PO | Single dose | — | 🌎 NA |
- Susceptible parasites: Feed at the rate of 10 lbs of premix per ton of food per 100 lbs of body weight.
羊
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Susceptible parasites | 10 mg/kg | PO | Single dose | — | 🌎 NA |
山羊
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Susceptible parasites | 0.44 grams morantel tartrate per 100 lb. body weight | PO | Single dose | — | 🌎 NA |
| Susceptible parasites | 10 mg/kg | PO | Single dose | — | 🌎 NA |
- Susceptible parasites: As a single therapeutic treatment. Conditions of constant worm exposure may require retreatment in 2-4 weeks.
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
概覽
酒石酸莫侖太爾 (Morantel tartrate) 是一種四氫嘧啶類驅蟲藥，主要用於反芻動物（牛、綿羊和山羊）以清除成熟的胃腸道線蟲。
- 主要標靶：成熟的捻轉血矛線蟲 (Haemonchus spp.)、奧斯特線蟲 (Ostertagia spp.)、毛圓線蟲 (Trichostrongylus spp.)、細頸線蟲 (Nematodirus spp.)、古柏線蟲 (Cooperia spp.) 和輻射食道口線蟲 (Oesophagostomum radiatum)。
- 臨床要點：與吡喹酮 (pyrantel) 密切相關，莫侖太爾專為反芻動物配製。它具有非常寬的安全範圍，通常可安全用於懷孕動物。
作用機轉
Morantel acts as a depolarizing neuromuscular blocking agent in susceptible parasites.
- Nicotinic Agonist: It possesses nicotine-like properties, mimicking acetylcholine at the parasite's neuromuscular junction → continuous depolarization → spastic paralysis of the worm → expulsion from the host's GI tract.
- Enzyme Inhibition: It also inhibits fumarate reductase in Haemonchus spp., disrupting the parasite's energy metabolism.
Note: Morantel has a slower onset of action compared to pyrantel but is approximately 100 times more potent.
安全性與警告
禁忌症
- No absolute contraindications
不良反應
- Increased respiratory rates (at high doses)
- Profuse sweating (at high doses)
- Ataxia (at high doses)
- Cholinergic effects (at high doses)
注意事項
Morantel is considered generally safe to use during pregnancy. Do not mix in feeds containing bentonite. Follow label directions for slaughter withdrawal times (e.g., 14 days for cattle).
藥物交互作用
Do not add to feeds containing bentonite.
Similar mechanism of action and toxicity; not recommended for concurrent use.
Similar mechanism of action and toxicity; not recommended for concurrent use.
Observation for adverse effects should be intensified if used concomitantly.
Observation for adverse effects should be intensified if used concomitantly.
Has antagonistic mechanism of action; do not use with morantel.
監測
- Efficacy of parasite clearance (e.g., fecal egg counts)
- Signs of cholinergic toxicity (only if massive overdose is suspected)
藥物動力學
吸收
Absorbed rapidly from the upper abomasum and small intestine. Peak levels occur about 4-6 hours after dosing.
分佈
Acts locally within the GI tract but is also absorbed systemically.
代謝
Promptly metabolized in the liver.
排除
Within 96 hours of administration, 17% of the drug is excreted in the urine with the remainder in the feces.
過量
Morantel tartrate has a large safety margin.
- Cattle: Dosages of up to 200 mg/kg (20 times recommended dose) resulted in no toxic reactions. Cattle receiving 2.5 times recommended dose for 2 weeks showed no toxic signs.
- Sheep: Doses of 4 times recommended were given with no detectable deleterious effects.
- Mice: The LD50 is 5 grams/kg.
Clinical signs of toxicity (if they occur) may include:
- Increased respiratory rates
- Profuse sweating (in species with sweat glands)
- Ataxia
- Other cholinergic effects
可用產品
劑型
- Medicated pellets
- Medicated premix
獸醫用
- Morantel Tartrate Medicated Pellets: 0.194% (880 mg/lb) in 3 lb and 10 lb bags (Goat Care-2X ®)
- Morantel Tartrate Medicated Premix: 88 grams morantel tartrate per lb. in 25 lb bags (Rumatel ® Medicated Premix-88)
各地核准狀態
暫無法規資料: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store at room temperature (15-30°C, 59-86°F) and protect from light unless otherwise instructed by the manufacturer.
飼主須知
- 用途：用於治療和控制牛、綿羊和山羊常見的胃腸道圓蟲。
- 給藥方式：通常作為含藥飼料顆粒或預混料給予。確保動物吃完所有的含藥飼料。
- 安全性：安全性極高，即使是懷孕動物也可使用。
- 停藥期：請仔細遵循標籤上有關屠宰停藥期的指示（例如某些牛用產品為 14 天）。在標籤劑量下通常沒有泌乳停藥期，但請務必與您使用的具體產品進行確認。
重要提示：請隨時提供新鮮的飲水。請勿將此藥物混合在含有膨潤土 (bentonite) 的飼料中。
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