莫匹羅星
莫匹羅星是一種具有獨特化學結構的局部抗生素，主要用於治療對其他藥物具抗藥性的細菌性皮膚感染（特別是葡萄球菌）。在人類醫學中，它被保留用於根除MRSA。**臨床警告**：僅在沒有其他替代治療選項時使用，且使用時間不應超過7天，以減少抗藥性的產生。
作用機制: Mupirocin blocks protein synthesis in bacteria by reversibly and specifically binding to and inhibiting **bacterial isoleucyl-tRNA synthetase** → prevents the incorporation of isoleucine into growing protein chains → halts bacterial growth and replication.
各物種劑量
- Bacterial skin infections (pyotraumatic dermatitis, intertrigo, callus pyoderma, acne) · Apply a thin layer of cream to infected areas · topical · q8h · Maximum 7 days · 10 minutes contact time is required for activity.
- Bacterial skin infections (including feline acne) · Apply a thin layer of cream to infected areas · topical · q8h · Maximum 7 days · 10 minutes contact time is required for activity.
劑量為合格獸醫專業人員的臨床參考。請務必對照最新藥品仿單及個別病患確認。
給藥途徑
禁忌症
- Patients with known renal impairment (due to potential systemic absorption of the polyethylene glycol vehicle in some ointment formulations)
- Deep puncture wounds or severe burns
不良反應
- Stinging sensation at the application site
- Local irritation or erythema
監測
- Resolution of clinical signs of skin infection
- Signs of local irritation or hypersensitivity at the application site
過量
Systemic toxicity from topical overdosage is highly unlikely due to minimal absorption and rapid metabolism of any absorbed drug. Ingestion may cause mild gastrointestinal upset. **Clinical Pearl:** The primary concern with excessive application is local irritation or potential toxicity from the polyethylene glycol (PEG) base in patients with renal compromise.
VetSheet 藥物參考供持牌獸醫專業人員作臨床決策輔助之用,不能取代專業判斷或廠方最新藥品說明書。