奧芬達唑
Oxfendazole
Oxfendazole (sulfoxide metabolite of fenbendazole)
別名: Synanthic · Benzelmin · RS 8858
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| For Oslerus osleri | 10 mg/kg PO once daily for 28 days. | PO | q24h | 28 days | 🌎 NA |
馬
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| For susceptible parasites | 10 mg/kg PO | PO | Single dose | — | 🌎 NA |
牛
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| For susceptible parasites | 4.5 mg/kg either PO or via intraruminal injection (22.5% only). May repeat in 4-6 weeks. Dose of the 9.06% suspension is 2.5 mL per 100 lb (50 kg) of body weight PO. Dose of the 22.5% suspension is 1 mL per 100 lb (50 kg) of body weight either PO or intraruminal injection. | PO/intraruminal | Single dose, may repeat in 4-6 weeks | — | 🌎 NA |
- For susceptible parasites: See package label for specific directions if giving by intraruminal injection.
豬
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| For susceptible parasites | 3-4.5 mg/kg PO | PO | Single dose | — | 🌎 NA |
羊
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| For susceptible parasites | 5 mg/kg PO | PO | Single dose | — | 🌎 NA |
山羊
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| For susceptible parasites | 7.5 mg/kg PO | PO | Single dose | — | 🌎 NA |
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
概覽
奧芬達唑是一種苯並咪唑類驅蟲藥，主要用於牛隻，以清除和控制肺線蟲、蛔蟲（包括奧斯特線蟲的抑制期幼蟲）及絛蟲。
- 廣效性：對多種致病性體內寄生蟲有效。
- 標籤外使用：常被用於馬、羊、山羊、豬及狗。
- 臨床要點：奧芬達唑是芬苯達唑的活性亞碸代謝物。與許多其他苯並咪唑類藥物相比，它在胃腸道的吸收更好，能達到更高的血漿濃度及更長的滯留時間。
作用機轉
Oxfendazole exerts its antiparasitic effects by disrupting intracellular microtubular transport systems within the parasite.
- Binds selectively to and damages tubulin → prevents tubulin polymerization → inhibits microtubule formation.
- At higher concentrations, it disrupts metabolic pathways and inhibits key metabolic enzymes, including malate dehydrogenase and fumarate reductase, ultimately depleting the helminth's energy reserves and causing death.
安全性與警告
禁忌症
- Female dairy cattle of breeding age
不良反應
- Hypersensitivity reactions (theoretically possible secondary to antigen release by dying parasites, particularly at high dosages)
注意事項
Warning: Not for use in female dairy cattle of breeding age. A 7-day slaughter withdrawal is required when using at labeled doses in cattle.
- Use cautiously in debilitated or sick horses.
- Hypersensitivity reactions may occur due to massive parasite die-off.
藥物交互作用
Concurrent use is contraindicated; abortions in cattle and death in sheep have been reported after using these compounds together.
監測
- Clinical efficacy (resolution of clinical signs, fecal egg counts)
藥物動力學
半衰期
吸收
Absorbed more readily from the GI tract compared to most other benzimidazole compounds. In dogs, peak levels occur at 8 hours post-administration.
分佈
In dogs, oxfendazole plasma concentrations are significantly higher and resident times longer than that of either fenbendazole or albendazole following single oral administration.
代謝
Absorbed oxfendazole is metabolized (and vice-versa) to the active compound, fenbendazole (sulfoxide) and the sulfone.
排除
Elimination half-life is reported to be about 7.5 hours in sheep and 5.25 hours in goats.
過量
Safety Profile: Oxfendazole has a wide margin of safety.
Doses of 10 times those recommended elicited no adverse reactions in horses tested. It is highly unlikely that this compound would cause serious acute toxicity when given alone.
可用產品
劑型
- Oral Suspension 9.06%
- Oral Suspension 22.5%
獸醫用
- Oxfendazole Oral Suspension: 9.06% (Synanthic)
- Oxfendazole Oral Suspension: 22.5% (Synanthic)
各地核准狀態
暫無法規資料: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store at room temperature and protect from light. Discard any unused suspension 24 hours after it has been reconstituted.
飼主須知
重要安全提示：不可用於預定作為人類食品用途的馬匹。
- 給藥方式：給藥前請將口服懸浮液徹底搖勻。
- 食用動物限制：牛隻必須嚴格遵守 7 天的屠宰停藥期。未獲 FDA 批准用於泌乳期乳牛。
- 副作用：不良反應極為罕見，但若您的動物在給藥後出現過敏反應跡象（例如面部腫脹、蕁麻疹、呼吸困難），請立即聯繫您的獸醫。
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