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硫代硫酸鈉

Sodium Thiosulfate

Sodium Hyposulfite

解毒劑IVPOSCTopical狗貓馬牛羊山羊

別名: natrii thiosulfas · natrium thiosulfuricum · sodium hyposulphite · sodium thiosulphate

由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本

經審核的 v13 劑量證據

經審核的非計算證據
經審核的非計算證據 (1)

僅供證據參考，不會自動計算

Halogen toxicoses

TABLE 128.6. Agent: Sodium thiosulfate. Dosage: 1% solution as continuous bath to effect52. Species/Comments: Halogen toxicoses.

bath
高風險須由已驗證獸醫確認drug_regimen方案年份 2019審核 dose-audit-mader-reviewed-v1

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概覽

硫代硫酸鈉是一種多功能解毒劑，在獸醫學中主要用於​氰化物​和​砷​中毒。

  • ​氰化物中毒​：通常單獨使用或與亞硝酸鈉合併使用。
  • ​重金屬中毒​：用於砷或銅中毒（與鉬酸鈉合併使用），儘管其對砷的療效尚有爭議。
  • ​化療藥物外滲​：用於減輕順鉑、卡鉑、放線菌素D和阿黴素外滲造成的組織損傷。
  • ​局部使用​：偶爾用於真菌感染（體癬）。

作用機轉

Sodium thiosulfate acts primarily as an exogenous sulfur donor.

  • Cyanide Antidote: It provides sulfur to the enzyme rhodanese (thiosulfate cyanide sulfurtransferase). Rhodanese catalyzes the conversion of highly toxic cyanide → relatively non-toxic thiocyanate ion, which is then safely excreted in the urine.
  • Heavy Metal Chelation: The sulfate moiety is presumed to react with and chelate metals like arsenic, facilitating their removal from the body.
  • Topical Antifungal: Activity is likely due to the slow release of colloidal sulfur.

安全性與警告

禁忌症

  • None absolute

不良反應

  • Profuse diarrhea (with large oral doses)

注意事項

There are no absolute contraindications. Injectable forms should be given slowly IV. Safe use during pregnancy has not been established (FDA Category C); use when benefits outweigh potential risks.

藥物交互作用

Cyanocobalamin

Not compatible when mixed together

監測

  • Clinical efficacy (resolution of toxicity signs)
  • Hydration status (if diarrhea occurs from oral dosing)

藥物動力學

吸收

Relatively poorly absorbed from the GI tract. When substantial doses are given PO, it acts as a saline cathartic.

分佈

Distributed in the extracellular fluid.

排除

Rapidly excreted via the urine.

過量

The drug is relatively non-toxic. Large doses by mouth may cause profuse diarrhea. Injectable forms should be given slowly IV.

可用產品

劑型

  • Injection
  • Crystals/Powder

人用標示

  • Sodium Thiosulfate for Injection: 10% (100 mg/mL, as pentahydrate) & 25% (250 mg/mL as pentahydrate) preservative-free in 10 mL & 50 mL single-use vials

各地核准狀態

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儲存與穩定性

Store at room temperature unless otherwise stated by the manufacturer. Crystals should be stored in tight containers. Not compatible mixed with cyanocobalamin.

飼主須知

硫代硫酸鈉通常在​醫院環境​中給予，用於中毒（如氰化物或砷）的緊急治療，或治療化療藥物外漏引起的組織損傷。

  • 如果您的寵物口服此藥物，可能會引起​嚴重腹瀉​。
  • 如果發生腹瀉，請確保您的寵物有充足的飲水，並密切遵循獸醫的指示。

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