่ก่็่ๅฌ่้ซ่ฃ่งฃ็ฉ
**่ก่็่ๅฌ่้ซ่ฃ่งฃ็ฉ (SPL)** ๆฏไธ็จฎไธป่ฆ็จๆผ็ธ้ซ็ฎ่็ง็ๆณจๅฐๅ็็ฉ่ฃฝๅ่ๅ ็ซๅบๆฟๅใๅฎ็นๅฅ้ฉ็จๆผๆฒป็็ฌ้ป**ๅ่ฆ็ผไฝ็็น็ผๆง่ก่็่่ฟ็ฎ็**๏ผ้ๅธธๆ่้ฉ็ถ็ๆ็็ด ็ๆณๅไฝตไฝฟ็จใ > **่จๅบ้้ป๏ผ** ๅจๆ็็ด ๆ่ฅๆง๏ผไพๅฆ MRSP - ่็ฒๆฐง่ฅฟๆๅไธญ้่ก่็่๏ผๆฅ็ๅขๅ ็ๆไปฃ๏ผๅ SPL ้ๆจฃ็ๅ ็ซ่ชฟ็ฏๅๆไพไบไธ็จฎๆๅนๅผ็่ผๅฉๆฒป็ๆนๅผ๏ผๆๅฉๆผๆธๅฐๅ จ่บซๆงๆ็็ด ไฝฟ็จ็้ ป็่็็จๆ้ใ ๆฌ็ขๅๆฏๅฉ็จ่ก่็่ๅฌ่้ซ่ฃ่งฃ้้ป่ฒ่ก่็่ (Cowan ่กๆธ ๅ I & III๏ผไบบ้ก่ๆ ช) ๅน้ค็ฉ่ฃฝๆใ่ฃฝๅ็ๆบถๆถฒๅซๆ้้ป่ฒ่ก่็่ๆๅ๏ผA ่็ฝ่ๅ็ฉ๏ผใๅฌ่้ซไปฅๅๆช้ๆฟพ็็ๅฟๆตธๆถฒ่ๆนฏ๏ผไธฆ็ถ้่ถ ๆฟพไปฅ้ๅฐ็ดฐ่ๅญธไธ็็ก่็ๆ ใ
ไฝ็จๆฉๅถ: SPL functions as an immunomodulator that specifically enhances **cell-mediated immunity** (Th1 immune response). * **Cytokine Stimulation:** It stimulates the production of key pro-inflammatory and immunoregulatory cytokines, including **Tumor Necrosis Factor (TNF-ฮฑ)**, **Interleukin-6 (IL-6)**, and **Interferon-gamma (IFN-ฮณ)**. * **Mechanism:** By upregulating IFN-ฮณ and TNF-ฮฑ, SPL enhances the phagocytic and bactericidal activities of macrophages and neutrophils โ leading to improved clearance of intracellular and extracellular staphylococcal organisms from the skin. * **Protein A Role:** The presence of staphylococcal Protein A acts as a potent B-cell superantigen and immunogen, further stimulating a robust host immune response against staphylococcal antigens.
ๅ็ฉ็จฎๅ้
- Labeled indications (Highly allergic patients) ยท Skin test with 0.05-0.1 mL intradermally. Therapy: Initially, 0.2 mL SC, then incremental increases of 0.2 mL once a week to 1 mL (a total of 5 injections). Then continue at 1 mL SC weekly for approximately 10-12 weeks. ยท SC/ID ยท Weekly ยท 10-12 weeks ยท Concomitant antibiotic therapy is recommended for an initial 4-6 week period. Maximum dose should be decreased in small dogs and can be increased cautiously, if necessary, in large dogs to 1.5 mL.
- Labeled indications (Non-allergic patients) ยท 0.5 mL SC twice weekly for 10-12 weeks, then 0.5-1 mL every 1-2 weeks. ยท SC ยท Twice weekly then every 1-2 weeks ยท 10-12 weeks initial, then maintenance ยท Concomitant antibiotic therapy is recommended for an initial 4-6 week period.
- Idiopathic, recurrent pyoderma ยท 0.5 mL SC twice weekly for 10-12 weeks, then tapered to effect. ยท SC ยท Twice weekly ยท 10-12 weeks then tapered ยท This agent is rarely needed, because in most cases, an underlying cause can be identified and treated.
- Chronic recurrent idiopathic pyoderma ยท Injections are administered twice weekly (0.5 mL) and slowly reduced to 0.5 mL every 2 weeks. ยท SC ยท Twice weekly then reduced ยท Ongoing ยท Pyoderma needs to be under control as this product is not a substitute for antibiotics.
ๅ้็บๅๆ ผ็ธ้ซๅฐๆฅญไบบๅก็่จๅบๅ่ใ่ซๅๅฟ ๅฐ็ งๆๆฐ่ฅๅไปฟๅฎๅๅๅฅ็ ๆฃ็ขบ่ชใ
็ตฆ่ฅ้ๅพ
็ฆๅฟ็
- Prior systemic hypersensitivity reactions to SPL
- Documented hypersensitivity reactions to beef products (contains unfiltered beef heart infusion broth)
ไธ่ฏๅๆ
- Post vaccine-type reactions (fever, malaise)
- Injection site reactions (redness, itching, swelling occurring 2-3 hours post-injection and persisting up to 3 days)
- Systemic hypersensitivity reactions (weakness, vomiting, diarrhea, severe itching, rapid breathing, fatigue/lassitude)
่ฅ็ฉ็ธไบไฝ็จ
- Cell-mediated immunosuppressive drugs (e.g., corticosteroids, cyclosporine) ยท May reduce the efficacy of SPL
็ฃๆธฌ
- Clinical efficacy (resolution of pyoderma)
- Local injection site reactions (redness, swelling, itching)
- Systemic hypersensitivity reactions (anaphylaxis, vomiting, weakness)
้้
No specific information was located regarding acute toxicity. Other than an increased risk for local or systemic hypersensitivity reactions, significant morbidity appears unlikely. Should an anaphylactic-type reaction occur, treat supportively; the manufacturer recommends **epinephrine** and **atropine** as antidotes.
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